71540-88-0Relevant academic research and scientific papers
Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers
Anikina, Lada V.,Vikharev, Yuri B.,Baranov, Vladimir V.,Malyshev, Oleg R.,Kravchenko, Angelina N.
, p. 317 - 319 (2018)
Racemic Albicar (2,6-diethyl-4,8-dimethylglycoluril) has been synthesized and resolved into enantiomers on a preparative scale by chiral HPLC. A comparison of the pharmacological effects of these compounds has been performed for the first time. It has been demonstrated that the (?)-(1S,5S)-enantiomer exerts a stimulating effect on the central nervous system due to activation of the serotonergic system, since it potentiates the effects of 5-hydroxytryptophan (the serotonin precursor), while the antagonist of serotonin receptors blocks its activity; the (+)-(1R,5R)-enantiomer evinces an inhibitory effect.
