10324-56-8

Upstream product

• 143-33-9 sodium cyanide 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 151-50-8 potassium cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 773837-37-9 sodium cyanide 

Downstream Products

• 125237-14-1 p,p'-bis(α-cyano(2,4-dichlorophenyl)methylhydrazinocarbonylmethoxy)diphenyl sulphone 
• 88965-93-9 2-amino-1-(2,4-dichlorophenyl)ethanol 
• 7554-78-1 2-(2,4-dichlorophenyl)-2-hydroxyacetic acid 
• 3876-14-0 5-(2,4-dichloro-phenyl)-4,5-dihydro-oxazol-2-ylamine 
• 900500-65-4 5-(2,4-dichloro-phenyl)-4-imino-3-methyl-oxazolidin-2-one 
• 10319-47-8 5-(2,4-dichloro-phenyl)-3-phenyl-oxazolidine-2,4-dione 

Relevant academic research and scientific papers

A magnetic nanoparticle catalyzed eco-friendly synthesis of cyanohydrins in a deep eutectic solvent

Magnetic Fe3O4 nanoparticles in deep eutectic solvents (DESs) have been regard as excellent catalysts for highly efficient cyanosilylation of various aldehydes and epoxides using trimethylsilyl cyanide TMSCN in high yields with excellent selectivity. Fe3O4 nanoparticles were synthesized and applied as a catalyst for the preparation of a wide variety of cyanohydrins (α-hydroxy nitriles and β-hydroxy nitriles) in readily available urea-choline chloride deep eutectic solvent DES as the most promising environmentally benign and cost-effective green solvent. Magnetic DES operates at very mild reaction conditions and can be easily recycled without significant loss of its catalytic activity.

NaCN/DOWEX(R)50WX4: A convenient system for synthesis of cyanohydrins from aldehydes

A variety of cyanohydrins were prepared from Aldehydes with sodium cyanide and DOWEX(R)50WX4 in a convenient procedure.

A new (R)-hydroxynitrile lyase from Prunus mume: Asymmetric synthesis of cyanohydrins

A new hydroxynitrile lyase (HNL) was isolated from the seed of Japanese apricot (Prunus mume). The enzyme has similar properties with HNL isolated from other Prunus species and is FAD containing enzyme. It accepts a large number of unnatural substrates (benzaldehyde and its variant) for the addition of HCN to produce the corresponding cyanohydrins in excellent optical and chemical yields. A new HPLC based enantioselective assay technique was developed for the enzyme, which promotes the addition of KCN to benzaldehyde in a buffered solution (pH=4.5).

Studies on agents with vasodilator and β-blocking activities. V. Synthesis and pharmacological activity of the optical isomers of TZC-5665

Synthesis of the four optical isomers of TZC-5665 (1), a candidate for the treatment of congestive heart failure, was achieved by the reaction of chiral diaminopyridazinone (2) with chiral glycidyl ether (3). The hypotensive and β-blocking activities of 1 and its optical isomers were examined when given intravenously into anesthetized rats. Furthermore these compounds were evaluated for inhibitory activity on cAMP phosphodiesterase III. Among the four optical isomers, R(A),S(B)-one (1c) possessed the essential activities of TZC-5665 (1).