1032426-96-2Relevant academic research and scientific papers
Palladium Nanoparticle-Catalyzed Stereoselective Domino Synthesis of 3-Allylidene-2(3 H)-oxindoles and 3-Allylidene-2(3 H)-benzofuranones
Parveen, Naziya,Sekar, Govindasamy
, p. 4682 - 4694 (2020)
A single-step, stereoselective protocol for the synthesis of unsymmetrically substituted (E)-3-allylideneoxindole and (E)-3-allylidenebenzofuran from readily accessible starting materials using palladium binaphthyl nanoparticles (Pd-BNPs) has been developed. Pd-BNP showing a wide range of functional group tolerance and an immense array of substrate scope have been explored with the successful synthesis of the drug molecule "tubulin polymerization inhibitor" free from trace metal impurities. The model reaction is extended to a gram-scale synthesis, and one of the products is utilized for derivatization. The Pd-BNP has been recycled up to 5 catalytic cycles without any loss in reaction yields and particle size of nanoparticles.
Synthesis, structure and emission properties of spirocyclic benzofuranones and dihydroindolones: A domino insertion-coupling-isomerization-Diels-Alder approach to rigid fluorophores
D'Souza, Daniel M.,Kiel, Alexander,Herten, Dirk-Peter,Rominger, Frank,Mueller, Thomas J. J.
, p. 529 - 547 (2008/12/22)
An alkynoyl ortho-iodo phenolester or alkynoyl ortho-iodo anilides and propargyl allyl ethers react under Sonogashira coupling conditions in the sense of an insertion-coupling-isomerization-Diels-Alder hetero domino reaction to furnish (tetrahydroisobenzo
