1310372-61-2Relevant academic research and scientific papers
Method for synthesizing nitrogen-containing multi-heterocyclic compound
-
Paragraph 0089; 0090; 0092, (2020/07/14)
The invention belongs to the field of chemical synthesis and discloses a method for compounding a nitrogenous polynary heterocyclic compound. The method comprises the following steps: (1) performing Ugi four-component reaction on aldehyde RCHO, iso-nitrile compound R'NC, o-halide arylamine and substituted propiolic acid R2-C is equivalent to C-CO2H under the solvent existence condition and removing the solvent after ending the reaction, thereby acquiring a product of the step (1); (2) performing consecutive reaction on the product acquired in the step (1) and 1,3-dipole reaction reagent underthe catalytic effect of cupric salt under the solvent existence condition and the inert atmosphere and then purifying the acquired reaction solution, thereby acquiring the product acquired in the step(2); (3) performing acid promotion reaction on the product acquired in the step (2) and the acid under a heating condition with or without solvent and purifying the acquired reaction solution after ending the reaction, thereby acquiring a target product. The method has wide substrate applicability; the preparation method is simple and efficient; the nitrogenous polynary heterocyclic compound hashigh functional group compatibility and wide popularizing prospect.
Copper-catalyzed tandem reaction of isocyanides with N-(2-haloaryl) propiolamides for the synthesis of pyrrolo[3,2-c]quinolin-4-ones
Zhou, Fengtao,Liu, Jianguang,Ding, Ke,Liu, Jinsong,Cai, Qian
experimental part, p. 5346 - 5353 (2011/08/05)
The copper-catalyzed tandem reaction of isocyanides with N-(2-haloaryl)propiolamides is very efficient for the synthesis of pyrrolo[3, 2-c]quinolin-4-ones. Highly reactive cyclic organocopper intermediates were proposed to be generated in the copper-catal
