1032473-53-2Relevant academic research and scientific papers
Iridium (III) complex-based fluorescent probe for detection of thiophenols and its application in water samples
Lu, Haiyue,Zhang, Daobin,Fan, Congbin,Guo, Yaqian,Xia, Xiaoli,Pu, Shouzhi
, p. 138 - 144 (2019)
In consideration of the nucleophilic capacity of thiophenols, which could cleave sulfonamide bond under neutral conditions, a cyclometalated iridium(III) complex (probe 1) comprised 2,4-dinitrobenzenesulfonamide (DNBS) as the recognition unit was designed
Dual functions of iridium(III) 2-phenylpyridine complexes: Metastasis inhibition and lysosomal damage
Chen, Shujiao,Ge, Xingxing,Hao, Yingying,Liu, Xicheng,Liu, Zhe,Tian, Laijin,Wu, Daiqun,Xie, Yaoqi,Yuan, Xiang-Ai,Zhang, Ying,Zhao, Jinmin
, (2020)
Six N-phenylcarbazole/triphenylamine-appended half-sandwich iridium(III) 2-phenylpyridine complexes ([(η5-Cp*)Ir(C^N)Cl]) were prepared and characterized. Compared with cisplatin, these complexes exhibited potential antitumor activity against A549 and HeLa tumor cells, with IC50 values (half-maximum inhibitory concentration) that changed from 2.8 ± 0.8 μM to 39.5 ± 2.7 μM, and could block the migration of tumor cells. These complexes also effectively bound to protein (binding constant: ~104 M? 1) and were transported through serum proteins, catalyzed the oxidation of coenzyme nicotinamide-adenine dinucleotide. Additionally, laser confocal microscopy and flow cytometry confirmed that these complexes possessed a non-energy-dependent cellular uptake mechanism, effectively accumulated in lysosomes (Pearson colocalization coefficient: ~0.74), damaged the integrity of acidic lysosomes, led to a change in the mitochondrial membrane potential, disrupted the cell cycle (G0/G1 phase), and eventually induced apoptosis. Above all, these complexes are potential antitumor agents with dual functions: metastasis inhibition and lysosomal damage.
Tuning the emission colour of triphenylamine-capped cyclometallated platinum(II) complexes and their application in luminescent oxygen sensing and organic light-emitting diodes
Wu, Wenting,Cheng, Chuanhui,Wu, Wanhua,Guo, Huimin,Ji, Shaomin,Song, Peng,Han, Keli,Zhao, Jianzhang,Zhang, Xin,Wu, Yubo,Du, Guotong
, p. 4683 - 4696 (2011/02/28)
[(Aryl-ppy)Pt(acac)] (ppy = 2-phenylpyridine, acac = acetylacetonato) derivatives with triphenylamine (TPA) substituents on the ppy ligand have been prepared. The TPA fragment is either directly cyclometallated (Pt-1) or attached to the ppy ligand through a C-C single bond (Pt-2) or a novel α-diketo group (Pt-3). All the complexes show room-temperature phosphorescence in fluid solution with emission bands in the range of 530-590 nm, which are red-shifted relative to the model complex [ppyPt(acac)] (λem = 486 nm). This emission colour tuning effect is attributed to either an elevated HOMO energy caused by electron-donating TPA substituents on the ppy ligand or a decreased LUMO energy caused by the electron-trap effect of electron-withdrawing substituents; both result in a smaller HOMO-LUMO energy gap and thus red-shifted emission. The complexes show extended luminescence lifetimes (τ = 3.0-5.5 μs) relative to the parent complex [ppyPt(acac)] (τ = 2.6 μs). The luminescent oxygen-sensing properties of the complexes were studied in solution and polymer films. White light emission was observed with an OLED device fabricated with complex Pt-3 with CIE coordinates of (0.32, 0.32). [(Aryl-ppy)Pt(acac)] complexes have been prepared that show room-temperature phosphorescence at 490-590 nm. The emission colour tuning effect is attributed to either the elevated HOMO energy or the decreased LUMO energy. The luminescent O2-sensing properties of the complexes in polymer films were studied. A white light-emitting OLED was fabricated with Pt-3 with a CIE of (0.32, 0.32).
