103253-15-2 Usage
Uses
Used in Pharmaceutical Industry:
L-655,240 is used as a thromboxane and prostaglandin endoperoxide antagonist for its ability to selectively target and inhibit these molecules, which are involved in various physiological processes and diseases.
Used in Drug Design:
L-655,240 is used as a structural and ligand-based design tool for the development of microsomal prostaglandins E synthase-1 inhibitors. This application aids in the creation of novel therapeutic agents that can potentially treat conditions related to the dysregulation of prostaglandins.
Biological Activity
Potent and selective thromboxane A 2 /prostaglandin endoperoxide receptor antagonist. pA 2 values are 8-8.4 in guinea pig smooth muscle; IC 50 = 7 nM for inhibition of human platelet aggregation. Orally active in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 103253-15-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,2,5 and 3 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 103253-15:
(8*1)+(7*0)+(6*3)+(5*2)+(4*5)+(3*3)+(2*1)+(1*5)=72
72 % 10 = 2
So 103253-15-2 is a valid CAS Registry Number.
InChI:InChI=1/C21H21ClFNO2/c1-13-17-10-16(23)8-9-18(17)24(12-14-4-6-15(22)7-5-14)19(13)11-21(2,3)20(25)26/h4-10H,11-12H2,1-3H3,(H,25,26)
103253-15-2Relevant academic research and scientific papers
Indole-2-alkanoic acids compositions of and anti allergic use thereof
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, (2008/06/13)
Indole-2-alkanoic acids are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, inflammation, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion and dismenorrhea and as cytoprotective agents.
