103253-15-2 Usage
Uses
L-655,240 is a selective and potent thromboxane and prostaglandin endoperoxide antagonist. Also used in the structure-based and ligand-based drug design for microsomal prostaglandins E synthase-1 inhibitors.
Biological Activity
Potent and selective thromboxane A 2 /prostaglandin endoperoxide receptor antagonist. pA 2 values are 8-8.4 in guinea pig smooth muscle; IC 50 = 7 nM for inhibition of human platelet aggregation. Orally active in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 103253-15-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,2,5 and 3 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 103253-15:
(8*1)+(7*0)+(6*3)+(5*2)+(4*5)+(3*3)+(2*1)+(1*5)=72
72 % 10 = 2
So 103253-15-2 is a valid CAS Registry Number.
InChI:InChI=1/C21H21ClFNO2/c1-13-17-10-16(23)8-9-18(17)24(12-14-4-6-15(22)7-5-14)19(13)11-21(2,3)20(25)26/h4-10H,11-12H2,1-3H3,(H,25,26)
103253-15-2Relevant articles and documents
Indole-2-alkanoic acids compositions of and anti allergic use thereof
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, (2008/06/13)
Indole-2-alkanoic acids are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, inflammation, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion and dismenorrhea and as cytoprotective agents.
