1032597-21-9Relevant articles and documents
Pd(II)-catalyzed cross-coupling of sp3 C-H bonds with sp 2 and sp3 boronic acids using air as the oxidant
Wang, Dong-Hui,Wasa, Masayuki,Giri, Ramesh,Yu, Jin-Quan
, p. 7190 - 7191 (2008/12/20)
O-Methyl hydroxamic acids, readily available from carboxylic acids, are found to be extremely reactive for β-C-H activation by Pd(OAc)2. This reactivity is exploited to develop the first example of cross-coupling sp3 C-H bonds with sp3 boronic acids. Air was shown to be a suitable stoichiometric oxidant for the catalytic oxidative coupling reaction. A biologically active natural product is readily converted to its novel analogues through this coupling reaction. Copyright