79791-29-0

Upstream product

• 25812-30-0 gemfibrozil 

Downstream Products

• 1174762-98-1 5-(2,5-dimethylphenoxy)-2,2-dimethyl-N-(perfluorophenyl)pentanamide 
• 1257521-31-5 5-(2,5-dimethylphenoxy)-2,2-dimethyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide 
• 1032597-21-9 C₁₆H₂₅NO₃ 
• 1416548-86-1 C₂₈H₃₇NO₃S 
• 1788861-30-2 1,3-dioxoisoindolin-2-yl 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoate 

Relevant academic research and scientific papers

Nickel-catalyzed direct thioetherification of β-C(sp3)-H bonds of aliphatic amides

The nickel-catalyzed β-thioetherification of unactivated C(sp3)-H bond of propionamides is established with the assistance of 8-aminoquinoline auxiliary, leading to the β-thio carboxylic acid derivatives. A broad range of functional groups is compatible with this thioetherfication reaction. The process represents the first successful example of metal-catalyzed C-S bond formation from unactivated C(sp3)-H bonds.

Remote Regioselective Radical C-H Functionalization of Unactivated C-H Bonds in Amides: The Synthesis of gem-Difluoroalkenes

The site-selective functionalization of unactivated aliphatic amines is an attractive and challenging synthetic approach. We herein report a general strategy for the remote site-selective functionalization of unactivated C(sp3)-H bonds in amides by photogenerated amidyl radicals to form gem-difluoroalkenes with trifluoromethyl-substituted alkenes. The site selectivity is controlled by a 1,5-hydrogen atom transfer (HAT) process of the amide. This photocatalyzed transformation shows both chemo- and site-selectivity, facilitating the formation of a secondary, tertiary, or quaternary carbon center.

Photoredox-Catalyzed Difunctionalization of Unactivated Olefins for Synthesizing Lactam-Substituted gem-Difluoroalkenes

Herein, the synthesis of lactam-substituted gem-difluoroalkenes has been developed through a photoredox-catalyzed radical cascade reaction. This developed photoredox-catalyzed, Br?nsted base-assisted intramolecular 5-exo-trig cyclization/intermolecular radical addition/β-fluoride elimination reaction offers a simple method for producing lactam, carbamate, or urea-substituted gem-difluoroalkenes with good functional group tolerance and high yields.

Metal-Free Photoinduced Hydroalkylation Cascade Enabled by an Electron-Donor-Acceptor Complex

A metal- A nd photocatalyst-free photoinduced radical cascade hydroalkylation of 1,7-enynes has been disclosed. The process is triggered by a single electron transfer (SET) event involving a photoexcited electron-donor-acceptor complex between an NHPI ester and a Hantzsch ester, which decomposes to afford a tertiary radical that is readily trapped by the enyne. The method provides an operationally simple, robust, and step-economical approach toward the construction of diversely functionalized dihydroquinolinones bearing quaternary centers. A sequential one-pot hydroalkylation-isomerization approach is also offered, giving access to a family of quinolinones. A wide substrate scope and high functional group tolerance were observed in both approaches.

Synthesis, characterization and evaluation of gemfibrozil-stilbene hybrid as antioxidant agent

Background: Oxidative stress and inflammation are important processes involved in cardiovascular disease. Antioxidant agents, like drugs or natural products from plants or plant-based food, represent a promising approach to treat these pathologies. Methods: In light of this, a gemfibrozil-stilbene hybrid (GEM-STIL) was synthesized as a strategy to combine the well-known antioxidant activity of stilbenes with the reported antioxidant and anti-inflammatory actions of fibrates such as gemfibrozil. The physicochemical properties, including aqueous solubility, partition coefficient, chemical stability and enzymatic hydrolysis of GEM-STIL have been studied and indicated that it is stable and has a good lipophilicity. The biological activity was also evaluated for its effect on C2C12 cell line viability and antioxidant activities. Results: The results indicated that GEM-STIL was well tolerated and induced a reduction of cell viability only at higher concentration (100 μg/ml). On the other hand, also at lower nontoxic concentrations (5, 25 and 50 μg/ml) exhibited a significant reduction of ROS production as well as a protective effect against the induced oxidative stimulus. Conclusion: These findings suggest that GEM-STIL is a potential new antioxidant agent useful in oxidative stress-related pathologies.

Acetophenone compounds, preparation methods thereof and application thereof in regulating blood lipid

The invention discloses a compound as shown in formula I or pharmaceutically acceptable salt and a preparation method thereof as well as application thereof in the preparation of drugs for regulatingblood lipid.

A General Approach to Site-Specific, Intramolecular C?H Functionalization Using Dithiocarbamates

Intramolecular hydrogen atom transfer is an established approach for the site-specific functionalization of unactivated, aliphatic C?H bonds. Transformations using this strategy typically require unstable intermediates formed using strong oxidants and have mainly targeted C?H halogenations or intramolecular aminations. Herein, we report a site-specific C?H functionalization that significantly increases the synthetic scope and convergency of reactions proceeding via intramolecular hydrogen atom transfer. Stable, isolable N-dithiocarbamates are used as precursors to amidyl radicals formed via either light or radical initiation to efficiently deliver highly versatile alkyl dithiocarbamates across a wide range of complex structures.

A General Approach to Quaternary Center Construction from Couplings of Unactivated Alkenes and Acyl Xanthates

A general, radical-mediated approach to quaternary center construction using unactivated alkenes as coupling partners is reported. In this strategy, acyl xanthates, readily accessed from carboxylic acids, serve as precursors to tertiary radicals. This strategy leverages the unique reactivity of xanthates to participate in efficient radical-mediated additions to unactivated alkenes, expanding the scope of quaternary center construction.

Aryloxy benzoic acids derivative and application of aryloxy benzoic acids derivative as FXR antagonist

The invention relates to an aryloxy benzoic acids derivative and application of the aryloxy benzoic acids derivative as a FXR antagonist, and particularly provides a compound as shown in a formula (I) or pharmaceutically acceptable salts and a preparation method thereof. The formula (I) is as shown in the specification, in the formula (I), R1 is selected from hydroxyl, methoxyl, ethyoxyl or amino, R2 is selected from hydrogen, halogen, nitro, carboxyl, methoxyl or methyl, X is selected from N or O, n1 is 0 or 1, and n2 is also 0 or 1. In addition, the compound as shown in the formula (I) or the pharmaceutically acceptable salts thereof have pharmacological effect of reducing blood fat, and is the FXR antagonist.

Copper(II)/Silver(I)-Catalyzed Sequential Alkynylation and Annulation of Aliphatic Amides with Alkynyl Carboxylic Acids: Efficient Synthesis of Pyrrolidones

A highly efficient protocol for the synthesis of pyrrolidones by the copper-catalyzed alkynylation/annulation of aliphatic amides with alkynyl carboxylic acids is discussed in this paper. A broad range of easily accessible alkynyl carboxylic acids were introduced at the β-methyl group of aliphatic amides with the assistance of an 8-aminoquinolyl auxiliary group via decarboxylation to achieve the subsequent cyclic C-N bond formation within one hour. High selectivity of β-methyl groups over methylene groups was observed, and the extension of this catalytic system to the activation of methylene C-H bonds failed. The substrates with two different groups at the α-position of the aliphatic amides lead to the formation of diastereoisomers which is determined by 1H NMR spectroscopy. The initially produced products with Z-configurations can be easily transformed to the corresponding products with E-configurations by the treatment with dilute p-toluenesulfonic acid after the reaction. This catalytic tandem decarboxylative cyclization provides a new opportunity for the direct functionalization of sp3 C-H bonds.