10326-57-5

Basic information

• Product Name: 1,3-DIMETHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBOXYLIC ACID
• Synonyms: AKOS BBS-00002690;AKOS BC-1832;1,3-DIMETHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBOXYLIC ACID
• CAS NO: 10326-57-5
• Molecular Formula: C14H12N2O2
• Molecular Weight: 240.26
• Mol File: 10326-57-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-DIMETHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DIMETHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBOXYLIC ACID(10326-57-5)
• EPA Substance Registry System: 1,3-DIMETHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBOXYLIC ACID(10326-57-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 10326-57-5(Hazardous Substances Data)

Usage

Chemical class

Belongs to the class of benzoimidazo[1,2-a]pyridines

Potential applications

Studied for their potential therapeutic applications

Biological activity

Has potential anti-tumor, anti-inflammatory, and anti-viral properties

Functional group

Contains a carboxylic acid group

Carboxylic acid group role

Common functional group in organic acids and often involved in biological processes

Structural features

1,3-dimethyl substitution on the benzene ring and the imidazo[1,2-a]pyridine ring system

Unique structure

The 1,3-dimethyl substitution and the imidazo[1,2-a]pyridine ring system contribute to the unique structure and potential function of this compound

Further research

Research on its properties and activities could provide valuable insights for potential pharmaceutical or industrial applications

Upstream product

• 4414-88-4 1H-benzimidazol-2-acetonitrile 
• 95-54-5 1,2-diamino-benzene 
• 16314-95-7 1,3-dimethyl-benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile 

Downstream Products

• 67220-02-4 1,3-Dimethylpyrido<1,2-a>benzimidazole 

Relevant articles and documents

Antioxidative and antiproliferative activities of novel pyrido[1,2-a]benzimidazoles

A series of pyrido[1,2-a]benzimidazoles has been designed, and novel examples are synthesized and evaluated for their potential antiproliferative activity against four human tumour cell lines—cervical (HeLa), colorectal (SW620), breast (MCF-7) and hepatocellular carcinoma (HepG2). In addition, their antioxidative potency has been evaluated by in vitro spectrophotometric assays. Preliminary structure–activity relationships among the synthesized compounds are discussed. Evaluation of their antioxidative capacity has shown that two compounds (25 and 26) possess promising reducing characteristics and free radical scavenging activity. Selective antiproliferative effect in the single-digit micromolar range was observed for compound 25 on MCF-7 (IC50=6μM) and HeLa (IC50=8μM) cell lines, comparable to the standards 5-fluorouracil and cisplatin. The combination of the radical scavenging activity and antiproliferative activity of compound 25 positions this compound as a potential lead candidate for further optimization.