651331-69-0

Basic information

• Product Name: 1H-Indole-3-tetradecanol, 4-methoxy-1-[(4-methoxyphenyl)sulfonyl]-
• CAS NO: 651331-69-0
• Molecular Formula: C30H43NO5S
• Molecular Weight: 529.741
• Mol File: 651331-69-0.mol

Chemical Properties

• CAS DataBase Reference: 1H-Indole-3-tetradecanol, 4-methoxy-1-[(4-methoxyphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-tetradecanol, 4-methoxy-1-[(4-methoxyphenyl)sulfonyl]-(651331-69-0)
• EPA Substance Registry System: 1H-Indole-3-tetradecanol, 4-methoxy-1-[(4-methoxyphenyl)sulfonyl]-(651331-69-0)

Safety Data

• Hazardous Substances Data: 651331-69-0(Hazardous Substances Data)

Upstream product

• 13362-52-2 1,13-tridecanediol 
• 116754-58-6 13-bromo-1-tridecylalcohol 
• 143702-35-6 (Z)-2-azido-3-(2-methoxyphenyl)acrylic acid methyl ester 
• 135-02-4 ortho-anisaldehyde 
• 651331-49-6 4-methoxy-1-(4-methoxybenzenesulfonyl)-1H-indole-3-carbaldehyde 
• 887604-02-6 (((13-bromotridecyl)oxy)methyl)benzene 
• 90734-97-7 4-methoxyindole-3-carboxaldehyde 
• 505-52-2 brassylic acid 
• 103260-65-7 4-methoxy-1H-indole-2-carboxylic acid 
• 4837-90-5 4-methoxy-1H-indole 
• 111258-23-2 methyl 4-methoxy-1H-indole-2-carboxylate 

Relevant articles and documents

INDOLE DERIVATIVES AND DRUGS CONTAINING THE SAME

An indole derivative represented by the following general formula (1) : wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents -(CH2)nOH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component. The indole derivative (1) of the present invention has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.

Effects of indole fatty alcohols on the differentiation of neural stem cell derived neurospheres

In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared, 13c (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.