832755-13-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-4-(methylsulfonyl)aniline is used as an intermediate in the synthesis of various pharmaceuticals for its unique chemical properties, contributing to the development of new drugs with specific therapeutic effects.
Used in Polymer Industry:
In the polymer industry, 2-Fluoro-4-(methylsulfonyl)aniline is used as a monomer or a building block in the production of specialty polymers, enhancing their properties such as thermal stability, chemical resistance, or other desired characteristics.

InChI:InChI=1/C7H8FNO2S/c1-12(10,11)5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3

Upstream product

• 29632-74-4 2-fluro-4-iodoaniline 
• 20277-69-4 sodium methansulfinate 
• 57946-56-2 2-fluoro-4-chloroaniline 
• 367-24-8 4-bromo-2-fluoroaniline 

Downstream Products

• 1001399-54-7 methyl 1-[2-fluoro-4-(methylsulfonyl)phenyl]-2-oxo-3-pyrrolidinecarboxylate 
• 1124329-11-8 9-cyclopentyl-2-{[2-fluoro-4-(methylsulfonyl)phenyl]amino}-7-methyl-7,9-dihydro-8H-purin-8-one 
• 1148005-91-7 C₂₄H₃₁FN₄O₆S 
• 1147553-38-5 C₂₄H₃₁FN₄O₆S 
• 1147553-57-8 C₂₄H₃₁FN₄O₆S 
• 733750-99-7 (2-fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitro-pyrimidin-4-yl}-amine 
• 1147885-39-9 [2-(4,6-dichloro-5-pyrimidinyl)ethyl][2-fluoro-4-(methylsulfonyl)phenyl]amine 
• 1001397-19-8 4-chloro-7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine 
• 1001397-14-3 6-chloro-N-[2-fluoro-4-(methylsulfonyl)phenyl]-5-(2-propen-1-yl)-4-pyrimidinamine 
• 1032825-02-7 1-bromo-2-fluoro-4-(methanesulfonyl)benzene 
• 1233322-91-2 C₂₄H₂₉FN₆O₃S 
• 834154-73-3 C₁₂H₁₁ClFN₃O₂S 
• 1236354-30-5 3-bromo-N-(2-fluoro-4-(methylsulfonyl)phenyl)imidazo[1,2-a]pyrazin-8-amine 
• 1236354-36-1 3-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-N-(2-fluoro-4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-a]pyrazin-8-amine 

Relevant academic research and scientific papers

HETEROCYCLIC CARBOXYLIC ACID AMIDE LIGAND AND APPLICATIONS THEREOF IN COPPER CATALYZED COUPLING REACTION OF ARYL HALOGENO SUBSTITUTE

Provided are a heterocyclic carboxylic acid amide ligand and applications thereof in a copper catalyzed coupling reaction. Specifically, provided are uses of a compound represented by formula (I), definitions of radical groups being described in the specifications. The compound represented by formula (I) can be used as the ligand in the copper catalyzed coupling reaction of the aryl halogeno substitute, and is used or catalyzing the coupling reaction for forming the aryl halogeno substitute having C—N, C—O, C—S and other bonds.

A New Class of Amide Ligands Enable Cu-Catalyzed Coupling of Sodium Methanesulfinate with (Hetero)aryl Chlorides

((2S,4R)-4-Hydroxy-N-(2-methylnaphthalen-1-yl)pyrrolidine-2-carboxamide (HMNPC), an amide derived from 4-hydroxy-L-proline and 2-methyl naphthalen-1-amine, is a powerful ligand for Cu-catalyzed coupling of (hetero)aryl halides with sulfinic acid salts, allowing for first time the metal-catalyzed coupling of (hetero)aryl chlorides and NaSO2Me. A considerable number of (hetero)aryl chlorides worked well, providing the pharmaceutically important (hetero)aryl methylsulfones in good to excellent yields.

NEW BICYCLIC COMPOUND FOR MODULATING G PROTEIN-COUPLED RECEPTORS

The present invention relates to a bicyclic compound for modulating G protein-coupled receptors. The inventive compound provides preventing or treating a disease associated with the modulation of G protein-coupled receptors, particularly GPR119 G protein-coupled receptors.

NEW BICYCLIC COMPOUND FOR MODULATING G PROTEIN-COUPLED RECEPTORS

The present invention relates to a bicyclic compound for modulating G protein-coupled receptors. The inventive compound provides preventing or treating a disease associated with the modulation of G protein-coupled receptors, particularly GPR119 G protein-coupled receptors.

GPR119 AGONISTS FOR THE TREATMENT OF DIABETES AND RELATED DISORDERS

The present invention relates to novel compounds that are useful in the treatment of metabolic disorders, particularly Type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds.

SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO

The present invention relates to certain substituted aryl and heteroaryl derivative of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complicati