103286-30-2Relevant articles and documents
Palladium-catalyzed phthalazinone synthesis using paraformaldehyde as carbon source
Wang, Huamin,Cai, Jinhui,Huang, Huawen,Deng, Guo-Jun
, p. 5324 - 5327 (2014)
A palladium-catalyzed one-pot synthesis of phthalazinones from 2-halomethyl benzoates, paraformaldehyde, and aryl hydrazines is described. Various substituted phthalazinones were selectively obtained in good yields using paraformaldehyde as the cheap carbon source (CH). (Chemical Equation Presented).
Access to phthalazinones via palladium-catalyzed three-component cycloamino-carbonylation of 2-formylaryl tosylates, hydrazines and CO
Liu, Bin,Zhang, Chunlei,Zhou, Xigeng
, p. 8282 - 8286 (2016/12/02)
The palladium-catalyzed three-component cycloaminocarbonylation of 2-formylaryl tosylates with hydrazines and carbon monoxide has been established, which provides an efficient method for synthesis of substituted phthalazinones. In addition, by applying this protocol as the key step, Hydralazine can easily be synthesized in 65% yield.