103293-60-3Relevant academic research and scientific papers
Stability investigations of alkyl 2,4-bisaryl-6-methyl-1,2,3,4- tetrahydropyrimidine-5-carboxylates
Goerlitzer,Heinrici
, p. 847 - 853 (2007/10/03)
The tetrahydropyrimidines (THPM) with an 4-(2-nitrophenyl) substituent 14 react with UV-A-light to yield the pyrimido[1,6-b]indazoles 16 and the cyclic hydroxamic acid 20 as a by-product. Irradiation of the 2,4-bis(2- nitrophenyl) THMP 2 do not give the 2,4-bis(2-nitrosophenyl)pyrimidine 26, but a mixture of the pyrimido[1,6-b]- and -[1,2-b]-indazoles 27 and 28. The products obtained by oxidation and reduction of the THPM are reported including the synthesis of pyrido[5,4-b]quinolines.
Studies on cerebral protective agents. I. Novel 4-arylpyrimidine derivatives with anti-anoxic and anti-lipid peroxidation activities
Kuno,Sugiyama,Katsuta,Kamitani,Takasugi
, p. 1452 - 1461 (2007/10/02)
Novel 4-arylpyrimidine derivatives were synthesized by the oxidation of 4-aryl-1,4-dihydropyrimidines, and their effects on anti-anoxic (AA) activity in mice and anti-lipid peroxidation (ALP) activity in rat brain mitochondria were investigated. Among these compounds, ethyl 6-methyl-2-phenyl-4-(4-pyridyl)-5-pyrimidinecarboxylate (4b) has AA activity (10mg/kg, i.p.) and ethyl 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylate (4f) has ALP activity (73% inhibition at 10-5 g/ml). The latter compound (100mg/kg, i.p.) was also effective on arachidonate-induced cerebral edema in rats with comparable potency to that of vitamin E.
Pyrimidine derivatives, processes for preparation thereof and composition containing the same
-
, (2008/06/13)
The invention relates to pyrimidine derivatives and their pharmaceutically acceptable salts which are useful in the treatment of cerebrovascular diseases, to processes for preparation thereof and to the composition containing the same, said pyrimidine der
