1032995-12-2Relevant academic research and scientific papers
A mitochondrial-targeting and NO-based anticancer nanosystem with enhanced photo-controllability and low dark-toxicity
Xu, Jiangsheng,Zeng, Fang,Wu, Hao,Wu, Shuizhu
, p. 4904 - 4912 (2015)
Compared to the generation of singlet oxygen in photodynamic therapy, photo-generation of nitric oxide (NO) would not be limited by the concentration of molecular oxygen. However, therapeutic applications of exogenous nitric oxide are usually limited by i
An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers
Fraix, Aurore,Kandoth, Noufal,Manet, Ilse,Cardile, Venera,Graziano, Adriana C.E.,Gref, Ruxandra,Sortino, Salvatore
supporting information, p. 4459 - 4461 (2013/06/26)
A multifunctional nanoplatform with four-in-one photoresponsive functionalities has been achieved through the co-encapsulation of two chromo-fluorogenic components within biocompatible polymeric nanoparticles. This engineered nanoconstruct efficiently delivers different photosensitizers in melanoma cells, which can be detected through their dual-color fluorescence, and induces amplified cell mortality due to the simultaneous photogeneration of singlet oxygen and nitric oxide.
Amplified nitric oxide photorelease in DNA proximity
Callari, Fiorella L.,Sortino, Salvatore
supporting information; body text, p. 1971 - 1973 (2009/02/04)
A novel bichromophoric conjugate integrating a NO photodonor and a DNA intercalator in its molecular skeleton, allows the light-controlled NO delivery nearby DNA and amplifies NO release via effective photoinduced energy transfer mechanism. The Royal Society of Chemistry.
