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ACT-PFK-076 is a novel, potent, and selective small molecule inhibitor of the enzyme pyruvate kinase M2 (PKM2), which plays a crucial role in cellular metabolism and cancer cell survival. This chemical has shown promising anticancer activity in preclinical studies by targeting the Warburg effect, a metabolic hallmark of cancer cells characterized by increased glycolysis and lactate production even in the presence of oxygen. By inhibiting PKM2, ACT-PFK-076 disrupts the metabolic reprogramming in cancer cells, leading to reduced tumor growth and increased sensitivity to other cancer therapies. Its potential as a therapeutic agent is currently under investigation in clinical trials for various cancer types, highlighting its significance in the field of oncology.

1033-75-6

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1033-75-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1033-75-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,3 and 3 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1033-75:
(6*1)+(5*0)+(4*3)+(3*3)+(2*7)+(1*5)=46
46 % 10 = 6
So 1033-75-6 is a valid CAS Registry Number.

1033-75-6Downstream Products

1033-75-6Relevant academic research and scientific papers

Design, synthesis, and antibacterial evaluation of PFK-158 derivatives as potent agents against drug-resistant bacteria

Wang, Wei,Zhang, You-Wen,Hu, Shang-Jiu,Niu, Wei-Ping,Zhang, Guo-Ning,Zhu, Mei,Wang, Ming-Hua,Zhang, Fan,Li, Xue-Mei,Wang, Ju-Xian

, (2021)

Infections caused by antibiotic resistant bacteria are a major health concern throughout the world. It is well known that PFK-158 can enhance the antibacterial effect of polymyxin, but its own anti-bactericidal effect is rarely discussed. In order to inve

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