1033010-15-9Relevant academic research and scientific papers
Asymmetric synthesis of telcagepant, a CGRP receptor antagonist for the treatment of migraine
Xu, Feng,Zacuto, Michael,Yoshikawa, Naoki,Desmond, Richard,Hoerrner, Scott,Itoh, Tetsuji,Journet, Michel,Humphrey, Guy R.,Cowden, Cameron,Strotman, Neil,Devine, Paul
experimental part, p. 7829 - 7841 (2011/02/22)
A highly efficient, asymmetric synthesis of telcagepant (1), a CGRP receptor antagonist for the treatment of migraine, is described. This synthesis features the first application of iminium organocatalysis on an industrial scale. The key to the success of
DIHYDROBENZOFURANYL DERIVATIVES AND METHODS OF THEIR USE
-
Page/Page column 20, (2008/12/06)
The present invention is directed to dihydrobenzofuranyl derivatives of formula I: or a pharmaceutically acceptable salt thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorder, cognitive disorder, diabetic neuropathy, pain, and other diseases or disorders.
