103318-68-9

Basic information

• Product Name: 3-Cyclopropylamino-2-(2-methylthiobenzoyl)acrylsaeure-ethylester
• CAS NO: 103318-68-9
• Molecular Weight: 305.398
• Mol File: 103318-68-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Cyclopropylamino-2-(2-methylthiobenzoyl)acrylsaeure-ethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Cyclopropylamino-2-(2-methylthiobenzoyl)acrylsaeure-ethylester(103318-68-9)
• EPA Substance Registry System: 3-Cyclopropylamino-2-(2-methylthiobenzoyl)acrylsaeure-ethylester(103318-68-9)

Safety Data

• Hazardous Substances Data: 103318-68-9(Hazardous Substances Data)

Upstream product

• 103318-67-8 (Z)-3-Ethoxy-2-(2-methylsulfanyl-benzoyl)-acrylic acid ethyl ester 
• 765-30-0 Cyclopropylamine 
• 1442-03-1 2-methylsulfanyl-benzoyl chloride 
• 104600-19-3 2-(2-Methylsulfanyl-benzoyl)-malonic acid diethyl ester 
• 103318-66-7 2-Methylthiobenzoylessigsaeure-ethylester 

Relevant articles and documents

Cycloaracylation of Enamines, I. - Synthesis of 4-Quinolone-3-carboxylic Acids

Starting with o-halobenzoyl chlorides 4 and open-chain secondary enamines 5, a new synthesis of 4-quinolone-3-carboxylic acids 12 is described.The reaction of 7-haloquinolone-3-carboxylic acids 12a-k with aliphatic amines 14 produces highly active antibacterial 7-aminoquinolone-3-carboxylic acids 15.The main product of the 1-cyclopropyl series, "ciprofloxacin" (15a), is being developed as a broad-spectrum chemotherapeutic agent.