1033418-69-7Relevant academic research and scientific papers
Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold
Nishiguchi, Gisele A.,Burger, Matthew T.,Han, Wooseok,Lan, Jiong,Atallah, Gordana,Tamez, Victoriano,Lindvall, Mika,Bellamacina, Cornelia,Garcia, Pablo,Feucht, Paul,Zavorotinskaya, Tatiana,Dai, Yumin,Wong, Kent
supporting information, p. 2328 - 2332 (2016/04/20)
The Pim proteins (1, 2 and 3) are serine/threonine kinases that have been found to be upregulated in many hematological malignancies and solid tumors. As a result of overlapping functions among the three isoforms, inhibition of all three Pim kinases has become an attractive strategy for cancer therapy. Herein we describe our efforts in identifying potent pan-PIM inhibitors that are derived from our previously reported pyridyl carboxamide scaffold as part of a medicinal chemistry strategy to address metabolic stability.
A modular flow reactor for performing Curtius rearrangements as a continuous flow process
Baumann, Marcus,Baxendale, Ian R.,Ley, Steven V.,Nikbin, Nikzad,Smith, Christopher D.,Tierney, Jason P.
experimental part, p. 1577 - 1586 (2008/10/09)
The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles. The Royal Society of Chemistry 2008.
