103342-27-4

Basic information

• Product Name: o-methoxycarbonyl benzyl sulfonyl chloride
• Synonyms: o-methoxycarbonyl benzyl sulfonyl chloride;2-Chlorosulfonylmethyl-benzoic acid methyl ester
• CAS NO: 103342-27-4
• Molecular Formula: C₉H₉ClO₄S
• Molecular Weight: 248.68
• Mol File: 103342-27-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: o-methoxycarbonyl benzyl sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: o-methoxycarbonyl benzyl sulfonyl chloride(103342-27-4)
• EPA Substance Registry System: o-methoxycarbonyl benzyl sulfonyl chloride(103342-27-4)

Safety Data

• Hazardous Substances Data: 103342-27-4(Hazardous Substances Data)

Usage

General Description

O-methoxycarbonyl benzyl sulfonyl chloride is a chemical compound with the molecular formula C9H9ClO4S. It is a benzyl sulfonyl chloride derivative, commonly used in organic synthesis as a reagent for the introduction of the o-methoxycarbonyl benzyl sulfonyl group into various compounds. o-methoxycarbonyl benzyl sulfonyl chloride is a versatile building block for the preparation of pharmaceuticals, agrochemicals, and materials. It is also used as a key intermediate in the synthesis of various bioactive molecules, making it an important reagent in the field of medicinal chemistry and chemical research. Due to its reactivity and specificity, o-methoxycarbonyl benzyl sulfonyl chloride is widely utilized in the production of complex organic compounds with specific functional groups.

Upstream product

• 85888-81-9 2-(chloromethyl)benzoic acid 
• 118-90-1 ortho-methylbenzoic acid 
• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 42908-86-1 2-Chloromethylbenzoyl chloride 
• 34040-62-5 o-(chloromethyl)benzoic acid methyl ester 
• 87-41-2 2-benzofuran-1(3H)-one 
• 21784-51-0 methyl 2-({[amino(imino)methyl]thio}methyl)benzoate hydrobromide 

Downstream Products

• 221449-10-1 C₃₅H₅₄N₈O₁₁S 
• 221449-08-7 C₃₄H₅₅N₇O₉S 
• 221449-15-6 C₃₁H₄₇N₇O₉S 
• 221449-05-4 C₂₇H₄₁N₇O₉S 
• 221449-12-3 C₂₇H₄₁N₇O₉S 
• 221448-89-1 C₂₄H₃₅N₇O₉S 
• 221448-87-9 C₂₅H₃₇N₇O₉S 

Relevant articles and documents

Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγInverse Agonist for Treatment of Castration-Resistant Prostate Cancer

We report the design, optimization, and biological evaluation of nuclear receptor RORγinverse agonists as therapeutic agents for prostate cancer treatment. The most potent compound 27 (designated as XY101) exhibited cellular activity with an IC50/su

Production method of methyl o-formate benzyl sulfonamide

The invention belongs to the technical field of pesticide intermediates, and particularly relates to a production method of methyl o-formate benzyl sulfonamide. The production method comprises steps:reacting o-methylbenzoic acid with sulfuryl chloride to obtain o-chloromethylbenzoic acid; reacting o-chloromethylbenzoic acid with methanol to obtain o-chloromethyl methyl benzoate; reacting o-chloromethyl methyl benzoate with sodium thiosulfate to obtain methyl o-formate benzyl mercaptan, reacting methyl o-formate benzyl mercaptan with chlorine to obtain methyl o-formate benzyl sulfonyl chloride, and reacting methyl o-formate benzyl sulfonyl chloride with ammonia gas to obtain methyl o-formate benzyl sulfonamide. According to the method, polychlorinated side reactions in the production process are reduced, the yield is increased, the tar yield is reduced, and the problems of low yield and high cost in the production process are solved.

Development of an immunoassay for the residues of the herbicide bensulfuron-methyl.

To develop a competitive indirect enzyme-linked immunosorbent assay based on polyclonal antibodies for the detection of the sulfonylurea herbicide bensulfuron-methyl, seven structurally related haptens were synthesized. Four of them mimicking the target analyte were conjugated to keyhole limpet hemocyanin by the N-hydroxysuccinimide activated ester method to use as immunogens, and all of them were conjugated to bovine serum albumin to use as plate-coating antigens. Polyclonal antibodies raised in rabbits and the coating antigens were screened and selected for the assay in simple homologous and heterologous ELISA formats. Three sensitive heterologous ELISAs were selected and optimized, showing the average IC(50) values of bensulfuron-methyl as low as 0.17, 0.09, and 0.09 ng/mL, the detection ranges of 0.04-0.60, 0.01-0.60, and 0.04-0.25 ng/mL, and the lowest detection limits of 0.03, 0.002, and 0.03 ng/mL, respectively. The cross-reactivities of other sulfonylurea herbicides and metabolites of bensulfuron-methyl to the antibodies were less than 15% in the two assays. Recoveries from the analyte-fortified water samples in assay I were in the range of 81-125% by simple dilution. The correlation between the ELISA and HPLC was 0.999 (n = 15) with a slope of 1.37 in the analysis of groundwater samples fortified with bensulfuron-methyl. The results obtained strongly indicate that the ELISA can be a highly sensitive and convenient tool for detecting bensulfuron-methyl residues in agricultural and environmental samples.