103344-71-4Relevant academic research and scientific papers
Diketo acids and their amino acid/dipeptidic analogues as promising scaffolds for the development of bacterial methionine aminopeptidase inhibitors
Masood, Mir Mohammad,Pillalamarri, Vijay K.,Irfan, Mohammad,Aneja, Babita,Jairajpuri, Mohamad Aman,Zafaryab,Rizvi, M. Moshahid A.,Yadava, Umesh,Addlagatta, Anthony,Abid, Mohammad
, p. 34173 - 34183 (2015/04/27)
Using diketoesters as the template, various derivatives were designed and the selected compounds were synthesized as bacterial methionine aminopeptidase (MetAP) inhibitors. The results of in vitro antibacterial screening revealed fifteen compounds (1a-c,
Synthesis and SAR of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids and esters and 2-amino-4-aryl-4-oxobut-2-enoic acids and esters: Potent inhibitors of kynurenine-3-hydroxylase as potential neuroprotective agents
Drysdale, Martin J.,Hind, S. Lucy,Jansen, Marilyn,Reinhard Jr., John F.
, p. 123 - 127 (2007/10/03)
The synthesis and structure-activity relationship of a series of 4-aryl- 2-hydroxy-4-oxobut-2-enoic acids and esters and 2-amino-4-aryl-4-oxobut-2- enoic acids and esters as potent inhibitors of kynurenine-3-hydroxylase are described. These compounds are
CHEMISTRY OF OXALYL DERIVATIVES OF METHYL KETONES. XLII. RING OPENING IN 5-ARYL-2,3-DIHYDRO-2,3-FURANDIONES BY THE ACTION OF AROMATIC AMINES IN TOLUENE. EFFECT OF SUBSTITUENTS IN THE NUCLEOPHILIC REAGENTS AND SUBSTRATE ON THE RATE OF THE NONCATALYTIC REAC
Kozlov, A. P.,Sychev, D. I.,Andreichikov, Yu. S.
, p. 1965 - 1972 (2007/10/02)
The kinetics of the reactions of 5-aryl-2,3-dihydro-2,3-furandiones with aromatic amines were investigated by a spectrophotometric method.On the basis of an analysis of the dependence of the reaction rate on the nature of the substituents in the substrate
