103344-72-5

Upstream product

• 99-90-1 para-bromoacetophenone 
• 95-92-1 oxalic acid diethyl ester 
• 55991-70-3 5-(4-bromo-phenyl)-furan-2,3-dione 

Downstream Products

• 147670-96-0 5-(4-Bromo-benzoyl)-2-phenyl-2H-pyrazole-3,4-dione 
• 188935-73-1 4-(4-Bromo-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid methyl ester 
• 1198396-88-1 C₂₁H₂₀BrNO₅S 
• 401635-90-3 4-(4-Bromo-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid 

Relevant academic research and scientific papers

Diketo acids and their amino acid/dipeptidic analogues as promising scaffolds for the development of bacterial methionine aminopeptidase inhibitors

Using diketoesters as the template, various derivatives were designed and the selected compounds were synthesized as bacterial methionine aminopeptidase (MetAP) inhibitors. The results of in vitro antibacterial screening revealed fifteen compounds (1a-c,

Reactions of acylpyruvic acids and 2,3-dihydrofuran-2,3-diones with 2,3-diaminopyridine

Acylpyruvic acids readily react with 2,3-diaminopyridine to form (Z)-3-acylmethylene-1H-3,4-dihydropyrido[2,3-b]pyrazin-2-ones. 5-Aryl-2,3-dihydrofuran-2,3-diones which can be regarded as lactones derived from γ-enolized aroylpyruvic acids react with 2,3-diaminopyridine under mild conditions, yielding regioisomeric (Z)-2-aroylmethylene-4H-1,2-dihydropyrido[2,3-b]pyrazin-3-ones. The structure of the products and reaction chemoselectivity are discussed.

CHEMISTRY OF OXALYL DERIVATIVES OF METHYL KETONES. XLII. RING OPENING IN 5-ARYL-2,3-DIHYDRO-2,3-FURANDIONES BY THE ACTION OF AROMATIC AMINES IN TOLUENE. EFFECT OF SUBSTITUENTS IN THE NUCLEOPHILIC REAGENTS AND SUBSTRATE ON THE RATE OF THE NONCATALYTIC REAC

The kinetics of the reactions of 5-aryl-2,3-dihydro-2,3-furandiones with aromatic amines were investigated by a spectrophotometric method.On the basis of an analysis of the dependence of the reaction rate on the nature of the substituents in the substrate