10335-26-9

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 87202-13-9 6,7-dimethoxy-1-(3-trimethylsilyl-2-propynyl)-2-(2-propynyl)-1,2,3,4-tetrahydroisoquinoline 
• 87202-15-1 6,7-dimethoxy-1,2-bis(2-propynyl)-1,2,3,4-tetrahydroisoquinoline 
• 14301-36-1 N-[2-(3,4-dimethoxyphenyl)ethyl]formamide 
• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 106488-65-7 3-Methoxy-6-dimethylaminomethylbenzenemethanol 
• 84859-42-7 2-hydroxymethyl-4-methoxyphenylacetic acid δ-lactone 
• 15175-54-9 N,N-dimethyl-4-methoxylbenzylamine 
• 106488-67-9 N-<2-(3,4-Dimethoxyphenyl)ethyl>-(4-methoxy-2-hydroxymethyl)phenylacetamide 
• 87202-20-8 5,6,13,13a-tetrahydro-2,3,10-trimethoxy-11,12-bis(trimethylsilyl)-8H-dibenzoquinolizine 
• 87202-19-5 5,6,13,13a-tetrahydro-2,3,10-trimethoxy-11-trimethylsilyl-8H-dibenzoquinolizine 

Relevant academic research and scientific papers

A Facile Synthesis of 7-Methoxyisochroman-3-one: Synthesis of 2,3-Dialkoxy-10-methoxyberbines

An easy two-step synthesis of 7-methoxyisochroman-3-one (2) is described starting from 4-methoxy-N,N-dimethylbenzylamine.The synthetic utility of 2 is demonstrated by synthesising two new 2,3-dialkoxy-10-methoxyberbines (5a and 5b).

AUXILIARY SILICON IN REGIOSELECTIVE COBALT CATALIZED PROTOBERBERINE SYNTHESES

η5-Cyclopentadienyl dicarbonyl cobalt catalyzes the cocyclization of 1,2-bis(propargyl)-1,2,3,4-tetrahydroisoquinolines 4b and 5 with alkynes to provide a novel synthetic entry into the tetrahydroprotoberberine nucleus.By judicious choice of trimethylsilyl substituents, regiocontrol in the D-ring can be achieved.Reaction of 4b with benzonitrile in the presence of the catalyst furnishes the rare isoquino-2,6-naphthyridine framework, also regioselectively.