103367-75-5Relevant academic research and scientific papers
Enantioselective synthesis of the C1-C11 fragment of bafilomycin A1 using non-wittig and desymmetrization strategies
Poupon, Jean-Christophe,Demont, Emmanuel,Prunet, Joelle,Ferezou, Jean-Pierre
, p. 4700 - 4707 (2007/10/03)
The synthesis of the C1-C11 fragment 33 of bafilomycin A1 was achieved. Intermediate ketone 16 was prepared in six steps from 4-oxopimelate 13. Desymmetrization of this ketone using Koga's chiral base followed by TMSCl quench furnished silyl en
Synthetic Studies Directed toward the Naturally Occurring Acyl Tetramic Acids. 1. Covergent Total Synthesis of (+/-)-Tirandamycin A
Boeckman, Robert K.,Starrett, John E.,Nickell, David G.,Sum, P.-E.
, p. 5549 - 5559 (2007/10/02)
An efficient convergent synthetic approach to the structurally unusual tetramic acid antibiotic tirandamycin A is described.Among the key features is the use of a rigid substituted cyclohexanone derivative as a vehicle to assure control of the relative st
