1033725-56-2Relevant academic research and scientific papers
Stereoselective synthesis of 2H-chromans by reductive deoxygenation of differently substituted 2-sulfinylmethylchroman-2-ols
Hernandez-Torres, Gloria,Carreno, M. Carmen,Urbano, Antonio,Colobert, Francoise
experimental part, p. 3864 - 3877 (2011/09/30)
Good-to-excellent diastereoselectivies have been achieved in the synthesis of 2H-chromans by Et3SiH/TMSOTf reductive deoxygenation of differently substituted 2-sulfinylmethylchroman-2-ols and their methyl ketals. The influence of both electron-
Sulfoxide-directed stereocontrolled access to 2H-chromans: Total synthesis of the (S,R,R,R)-enantiomer of the antihypertensive drug nebivolol
Carreno, M. Carmen,Hernandez-Torres, Gloria,Urbano, Antonio,Colobert, Francoise
supporting information; experimental part, p. 2035 - 2038 (2009/04/04)
A homochiral sulfoxide-directed reductive deoxygenation of 2-(p-tolylsulfinyl)methyl-2-chromanols allows the stereoselective formation of 2H-chromans with up to 95:5 diastereoisomeric ratio. This new methodology was applied in a short and convergent enantioselective synthesis of the (S,R,R,R)-enantiomer of the antihypertensive drug Nebivolol. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
