103373-52-0

Upstream product

• 394-47-8 2-fluorobenzonitrile 
• 62-53-3 aniline 
• 1581-13-1 2-amino-2'-fluorobenzophenone 
• 124676-19-3 2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine 
• 621-84-1 O-benzyl carbamate 

Downstream Products

• 103343-84-6 (3RS)-3-amino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one 
• 103373-53-1 <5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester 
• 111139-85-6 6-(2-Fluorophenyl)-4-(indol-2-yl)carbonylamino-1-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine 
• 111113-11-2 6-(2-Fluorophenyl)-4-(indol-2-yl)carbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine 
• 111113-23-6 N-<5-(2-fluorophenyl)-2-hydrazono-3H-1,4-benzodiazepin-3-yl>-1H-indole-2-carboxamide 
• 111113-16-7 6-(2-Fluorophenyl)-4-benzyloxycarbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine 
• 111113-14-5 [5-(2-Fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester 
• 111113-12-3 6-(2-Fluorophenyl)-4-(4-chlorophenyl)carbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine 
• 103373-60-0 N-<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>-1H-indole-2-carboxamide 
• 103373-58-6 1,3-Dihydro-5-(2-fluorophenyl)-3-(4-chlorophenyl)-carbonylamino-2H-1,4-benzodiazepin-2-thione 
• 103373-59-7 1,3-dihydro-5-(2-fluorophenyl)-3-(RS)-amino-2H-1,4-benzodiazepin-2-thione 
• 1057707-02-4 [3-Benzyloxycarbonylamino-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester 

Relevant academic research and scientific papers

COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS

The present invention relates to pharmaceutical agents administered to a subject either in combination or in series for the treatment of a Respiratory Syncytial Virus (RSV) infection, wherein treatment comprises administering a compound effective to inhibit the function of the RSV and an additional compound or combinations of compounds having anti-RSV activity.

BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Benzodiazepine analogs

Benzodiazepine analogs of the formula: STR1 are disclosed which are antagonists of gastrin and cholecystokinin (CCK).

Process for 3-acylamino benzodiazepines

The present invention provides an improved process for producing 3-acylamino benzodiazepines of the formula: STR1 wherein: R is loweralkyl of from 1-6 carbon atoms, aryl such as phenyl and halophenyl, aralkyl, alkyloxy, aralkyloxy, indolyl or substituted