(3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one

Base Information

• Chemical Name: (3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one
• CAS No.: 103373-52-0
• Molecular Formula: C₂₃H₁₈FN₃O₃
• Molecular Weight: 403.413
• Mol file: 103373-52-0.mol

Synonyms:(3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one

Chemical Property of (3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one

There total 7 articles about (3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2-amino-2'-fluorobenzophenone (1581-13-1) + 2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine (124676-19-3) → (3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one (103373-52-0)

Guidance literature:

2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 0 ℃; for 1h;

2-amino-2'-fluorobenzophenone; With 4-methyl-morpholine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With ammonium hydroxide; In methanol; for 2h;

Reference yield:

2-amino-2-fluorobenzophenone → (3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one (103373-52-0)

Guidance literature:

Reference yield:

O-benzyl carbamate (621-84-1) → (3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one (103373-52-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 2 h / 120 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 0 °C

2.2: 1 h / 0 - 20 °C

2.3: 2 h

With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;

upstream raw materials:

O-benzyl carbamate

2-amino-2'-fluorobenzophenone

2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine

aniline

Downstream raw materials:

[3-Benzyloxycarbonylamino-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

(3RS)-3-amino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one

<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester

[5-(2-Fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester