1033747-90-8

Basic information

• Product Name: 2-Oxo-1,2-dihydroquinoline-7-carbonitrile
• Synonyms: 2-Oxo-1,2-dihydroquinoline-7-carbonitrile;2-Hydroxyquinoline-7-carbonitrile
• CAS NO: 1033747-90-8
• Molecular Formula: C10H6N2O
• Molecular Weight: 170.17
• Mol File: 1033747-90-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Oxo-1,2-dihydroquinoline-7-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxo-1,2-dihydroquinoline-7-carbonitrile(1033747-90-8)
• EPA Substance Registry System: 2-Oxo-1,2-dihydroquinoline-7-carbonitrile(1033747-90-8)

Safety Data

• Hazardous Substances Data: 1033747-90-8(Hazardous Substances Data)

Usage

Uses

Used in Scientific Research:
2-Oxo-1,2-dihydroquinoline-7-carbonitrile is used as a scientific reagent for its unique chemical properties in the field of organic chemistry. It is employed in lab-based research to explore its potential applications and reactions with other compounds.
Used in Industrial Chemical Reactions:
In the chemical industry, 2-Oxo-1,2-dihydroquinoline-7-carbonitrile is used as a reactant or intermediate in the synthesis of various organic compounds. Its specific structure and functional groups make it a valuable component in the development of new chemical products.
Note: Due to the limited information available on the chemical applications and potential health implications of 2-Oxo-1,2-dihydroquinoline-7-carbonitrile, its uses are primarily restricted to scientific research and industrial chemical reactions. Further studies are needed to fully understand its properties and potential applications in other industries.

Upstream product

• 22246-18-0 7-hydroxy-3,4-dihydro-2-(1H)-quinolinone 
• 903557-01-7 2-oxo-1,2,3,4-tetrahydroquinoline-7-carbonitrile 
• 882023-50-9 2-oxo-1,2,3,4-tetrahydroquinolin-7-yl trifluoromethanesulfonate 
• 104-85-8 para-methylbenzonitrile 
• 939-79-7 4-cyano-2-nitrotoluene 
• 105191-34-2 3-(4-cyano-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester 
• 1033747-92-0 3-hydroxy-2-oxo-1,2,3,4-tetrahydro-quinoline-7-carbonitrile 
• 99465-10-8 7-bromo-1,2-dihydroquinolin-2-one 

Relevant articles and documents

Oxidative Aromatization of 3,4-Dihydroquinolin-2(1 H)-ones to Quinolin-2(1 H)-ones Using Transition-Metal-Activated Persulfate Salts

Inorganic persulfate salts were identified as efficient reagents for the oxidative aromatization of 3,4-dihydroquinolin-2(1H)-ones through the activation of readily available transition metals, such as iron and copper. The feasible protocol conforming to the requirement of green chemistry was utilized in the preparation of the key intermediate (7-(4-chlorobutoxy)quinolin-2(1H)-one 2) of brexpiprazole in 80% isolated yield on a 100 g scale, and different quinolin-2(1H)-one derivatives with various functional groups were demonstrated in 52-89% yields.

Development of the Convergent, Kilogram-Scale Synthesis of an Antibacterial Clinical Candidate Using Enantioselective Hydrogenation

Early chemical development studies into the best way of assembling AZD9742, an antibacterial drug candidate, have involved swapping the order of two reductive aminations. The orthogonally functionalized aminopiperidine partner for these couplings is now enantioselectively synthesized using ruthenium-catalyzed asymmetric hydrogenation. The challenge of controlling defluorination through an appropriate catalyst choice has hitherto prevented this revised sequence from reaching its full potential. However, it is still shown to allow access to the active pharmaceutical ingredient in a stereochemically pure form and has been demonstrated on a multikilogram scale. The reductive aminations in both the original and revised sequences provided different scale-up challenges, and the solutions implemented are described.

INHIBITORS OF DNA GYRASE FOR THE TREATMENT OF BACTERIAL INFECTIONS

The present invention relates to compounds which specifically inhibit bacterial DNA Gyrase and can be used for the treatment of respiratory tract infections.

Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced p K a: Antibacterial agents with an improved safety profile

Novel non-fluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) are of interest for the development of new antibacterial agents that are not impacted by target-mediated cross-resistance with fluoroquinolones. N-L

2-QUINOLINONE AND 2-QUINOXALINONE- DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS

The present invention relates to compounds of Formula (I) : and pharmaceutically acceptable salts thereof, to their use in the treatment of bacterial infections, and to their methods of preparation.

SUBSTITUTED PIPERIDINE DERIVATIVES AND THEIR USE AS ANTIBATERIAL AGENTS

The present invention relates to compounds of Formula (I):and pharmaceutically acceptable salts thereof, and to their use in the treatment of bacterial infections.