99465-10-8

Basic information

• Product Name: 7-BROMOQUINOLIN-2(1H)-ONE
• Synonyms: 7-BROMOQUINOLIN-2(1H)-ONE;7-Bromo-2(1H)-quinolinone;7-Bromo-2-hydroxyquinoline;7-broMoquinolin-2-ol;2(1H)-Quinolinone, 7-broMo-;7-broMo-1,2-dihydroquinolin-2-one;7-BroMo-1H-quinolin-2-one
• CAS NO: 99465-10-8
• Molecular Formula: C₉H₆BrNO
• Molecular Weight: 224.06
• Mol File: 99465-10-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 270-272℃
• Boiling Point: 375.391°C at 760 mmHg
• Flash Point: 180.83°C
• Appearance: /
• Density: 1.620
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 10.91±0.70(Predicted)
• CAS DataBase Reference: 7-BROMOQUINOLIN-2(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMOQUINOLIN-2(1H)-ONE(99465-10-8)
• EPA Substance Registry System: 7-BROMOQUINOLIN-2(1H)-ONE(99465-10-8)

Safety Data

• Hazardous Substances Data: 99465-10-8(Hazardous Substances Data)

Usage

General Description

7-Bromoquinolin-2(1H)-one is a chemical compound that belongs to the class of quinolone derivatives. It is an organic compound with the molecular formula C9H6BrNO and a molar mass of 220.05 g/mol. It is a white to light yellow solid that is used in various chemical and pharmaceutical applications. 7-BROMOQUINOLIN-2(1H)-ONE has a bromine atom and a carbonyl group attached to a quinoline ring, giving it unique properties and reactivity. It is also known to have antimicrobial and antifungal properties and is used in the synthesis of various biologically active compounds. Overall, 7-Bromoquinolin-2(1H)-one is an important chemical with diverse applications in different industries.

InChI:InChI=1/C9H6BrNO/c10-7-3-1-6-2-4-9(12)11-8(6)5-7/h1-5H,(H,11,12)

Upstream product

• 1068437-24-0 methyl (2E)-3-(2-amino-4-bromophenyl)prop-2-enoate 
• 14548-51-7 7-bromo-3,4-dihydroquinoline-2(1H)-one 
• 860720-24-7 7-bromoquinoline 1-oxide 
• 349426-35-3 N-(3-bromophenyl)cinnamamide 
• 917341-34-5 (2E)-N-(3-bromophenyl)-3-phenylprop-2-enamide 
• 99455-15-9 7-bromo-2-chloro-quinoline 
• 591-19-5 m-Bromoaniline 
• 349426-35-3 N-(3-bromophenyl)cinnamamide 
• 99465-18-6 (E)-N-(3-bromophenyl)-3-ethoxypropenamide 
• 1094851-40-7 ethyl 3-(2-amino-4-bromophenyl)acrylate 
• 1094851-38-3 ethyl 3-(4-bromo-2-nitrophenyl)acrylate 
• 4965-36-0 7-bromoquinoline 

Downstream Products

• 99455-15-9 7-bromo-2-chloro-quinoline 
• 1068437-26-2 7-bromo-1-(tert-butoxycarbonyl)quinolin-2(1H)-one 
• 1426083-03-5 7-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-4-yl}-quinolin-2-ol 
• 1219130-54-7 7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-quinolin-2-ol 
• 1219130-54-7 7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-quinolin-2-one 
• 1613317-24-0 2-cyclohexyl-N-[7-(4-phenylthiazol-2-yl)quinolin-2-yl]succinamic acid 
• 1613317-41-1 7-(4-phenylthiazol-2-yl)quinolin-2-ylamine 
• 1613317-40-0 2-chloro-7-(4-phenylthiazol-2-yl)quinoline 
• 1613317-39-7 7-(4-phenylthiazol-2-yl)-1H-quinolin-2-one 
• 1223559-68-9 7-bromo-2-ethoxyquinoline 
• 116632-53-2 7-bromoquinolin-2-amine 
• 1033747-90-8 2-oxo-1,2-dihydro-quinoline-7-carbonitrile 
• 99455-13-7 5-bromo-2-chloroquinoline 
• 99455-08-0 7-bromo-2-methoxyquinoline 

Relevant articles and documents

Oxidative Aromatization of 3,4-Dihydroquinolin-2(1 H)-ones to Quinolin-2(1 H)-ones Using Transition-Metal-Activated Persulfate Salts

Inorganic persulfate salts were identified as efficient reagents for the oxidative aromatization of 3,4-dihydroquinolin-2(1H)-ones through the activation of readily available transition metals, such as iron and copper. The feasible protocol conforming to the requirement of green chemistry was utilized in the preparation of the key intermediate (7-(4-chlorobutoxy)quinolin-2(1H)-one 2) of brexpiprazole in 80% isolated yield on a 100 g scale, and different quinolin-2(1H)-one derivatives with various functional groups were demonstrated in 52-89% yields.

Palladium-catalyzed synthesis of quinolin-2(1: H)-ones: the unexpected reactivity of azodicarboxylate

Quinolin-2(1H)-one is a useful structure unit present in a wide range of natural products and pharmaceuticals. A Pd(ii)-catalyzed synthesis of quinolin-2(1H)-ones from quinoline N-oxides was developed with azodicarboxylates which act as both the activating agent and oxidant. The reaction proceeded under mild conditions and no protection against air and moisture was needed.

CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE 1 INHIBITORS

The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.