1033766-41-4Relevant academic research and scientific papers
SN1 reactions in supercritical carbon dioxide in the presence of alcohols: The role of preferential solvation
Delgado-Abad, Thais,Martínez-Ferrer, Jaime,Acerete, Rafael,Asensio, Gregorio,Mello, Rossella,González-Nú?ez, María Elena
, p. 6554 - 6560 (2016)
Ethanol (3b) inhibits SN1 reactions of alkyl halides 1 in supercritical carbon dioxide (scCO2) and gives no ethers as products. The unexpected behaviour of alcohols 3 in the reaction of alkyl halides 1 with 1,3-dimethoxybenzene (2) in scCO2 under different conditions is rationalised in terms of Br?nsted and Lewis acid-base equilibria of reagents, intermediates, additives and products in a singular solvent characterised by: (i) the strong quadrupole and Lewis acid character of carbon dioxide, which hinders SN2 paths by strongly solvating basic solutes; (ii) the weak Lewis base character of carbon dioxide, which prevents it from behaving as a proton sink; (iii) the compressible nature of scCO2, which enhances the impact of preferential solvation on carbon dioxide availability for the solvent-demanding rate determining step.
Microwave-accelerated alkylation of arenes/heteroarenes with benzylic alcohols using antimony(III) chloride as catalyst: Synthesis of O-heterocycles
Shukla, Prashant,Choudhary, Manoj K.,Nayak, Sandip K.
supporting information; experimental part, p. 1585 - 1591 (2011/08/03)
An efficient protocol for alkylation of electron-rich arenes/heteroarenes with benzylic alcohols under microwave irradiation using antimony(III) chloride as catalyst has been developed. The mild reaction conditions, high yields, operational simplicity, and applicability to various substrates render the approach a useful route for the synthesis of diaryl/triarylalkane. In addition, a new route for the conversion of ortho-alkenylated phenols into functionalized O-heterocycles has been accomplished. Georg Thieme Verlag Stuttgart ? New York.
A novel InCl3/SiO2-catalyzed hydroarylation of arenes with styrenes under solvent-free conditions
Sun, Gaojun,Sun, Huayin,Wang, Zhiyong,Zhou, Ming-Ming
experimental part, p. 1096 - 1100 (2009/04/04)
A novel InCl3/SiO2-catalyzed hydroarylation of various styrenes with arenes has been developed. The reaction can be carried out under solvent-free conditions to afford a series of 1,1-diarylalkanes in high yields and with good regioselectivities. The catalyst can be reused six times without obvious loss of catalytic activity. Georg Thieme Verlag Stuttgart.
