10338-65-5Relevant articles and documents
Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive
Han, Dongyang,Li, Sasa,Xia, Siqi,Su, Mincong,Jin, Jian
supporting information, p. 12349 - 12354 (2020/09/09)
An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodology features a simple NiII salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides were coupled successfully with primary and secondary alkyl amines, and anilines in good to excellent yields. Similarly, benzophenone imine gave the corresponding N-arylation product in an excellent yield.
Direct sulfonylation of anilines mediated by visible light
Johnson, Tarn C.,Elbert, Bryony L.,Farley, Alistair J. M.,Gorman, Timothy W.,Genicot, Christophe,Lallemand, Bénédicte,Pasau, Patrick,Flasz, Jakub,Castro, José L.,Maccoss, Malcolm,Dixon, Darren J.,Paton, Robert S.,Schofield, Christopher J.,Smith, Martin D.,Willis, Michael C.
, p. 629 - 633 (2018/01/28)
Sulfones feature prominently in biologically active molecules and are key functional groups for organic synthesis. We report a mild, photoredox-catalyzed reaction for sulfonylation of aniline derivatives with sulfinate salts, and demonstrate the utility of the method by the late-stage functionalization of drugs. Key features of the method are the straightforward generation of sulfonyl radicals from bench-stable sulfinate salts and the use of simple aniline derivatives as convenient readily available coupling partners.
