70291-67-7

Basic information

• Product Name: 4-(4-CHLOROPHENYL)MORPHOLINE
• Synonyms: 4-(4-CHLOROPHENYL)MORPHOLINE
• CAS NO: 70291-67-7
• Molecular Formula: C₁₀H₁₂ClNO
• Molecular Weight: 197.66138
• EINECS: 200-110-4
• Product Categories: pharmacetical
• Mol File: 70291-67-7.mol
• Article Data: 42

Chemical Properties

• Melting Point: 73 °C
• Boiling Point: 323.885°C at 760 mmHg
• Flash Point: 149.681°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.556
• Solubility: soluble in Toluene
• CAS DataBase Reference: 4-(4-CHLOROPHENYL)MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-CHLOROPHENYL)MORPHOLINE(70291-67-7)
• EPA Substance Registry System: 4-(4-CHLOROPHENYL)MORPHOLINE(70291-67-7)

Safety Data

• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 70291-67-7(Hazardous Substances Data)

Usage

General Description

4-(4-chlorophenyl)morpholine is a chemical compound with the molecular formula C11H13ClNO. It is a heterocyclic compound consisting of a morpholine ring with a 4-chlorophenyl substituent. This chemical has a wide range of applications, including as an intermediate in the synthesis of pharmaceuticals and agrochemicals, as a corrosion inhibitor, and as a reagent in organic synthesis. It is also used as a building block in the production of various chemical compounds. Additionally, 4-(4-chlorophenyl)morpholine has been studied for its potential pharmacological properties, including its activity against certain diseases and biological targets. Overall, this compound plays a significant role in the fields of chemistry, pharmacology, and materials science.

InChI:InChI=1/C10H12ClNO/c11-9-1-3-10(4-2-9)12-5-7-13-8-6-12/h1-4H,5-8H2

Upstream product

• 698-69-1 4-chloro-N,N-dimethylaniline 
• 7460-82-4 diethylene glycol ditosylate 
• 109-02-4 4-methyl-morpholine 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 21700-74-3 (p-chlorophenyl)triethoxysilane 
• 1446818-96-7 5-chloro-2-(morpholin-4-yl)benzaldehyde 
• 96515-79-6 5-chloro-2-fluorobenzaldehyde 
• 92-53-5 4-Phenylmorpholine 
• 2632-70-4 di-p-chlorophenyl zinc 
• 110-91-8 morpholine 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 1679-18-1 4-Chlorophenylboronic acid 
• 34604-52-9 diethylene glycol dimesylate 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 1070716-76-5 3-(1,3-benzodioxol-5-yl)-2-methyl-2-[4-(4-morpholinyl)phenyl]propanal 
• 304675-41-0 N-(4-morpholinophenyl)-N'-phenylurea 
• 27347-14-4 N-(4-methoxyphenyl)morpholine 
• 10338-65-5 4-(4-(methylsulfonyl)phenyl)morpholine 
• 1220095-37-3 4-[4-(trimethylsilyl)phenyl]morpholine 
• 92-53-5 4-Phenylmorpholine 
• 28276-90-6 2-(N-(4-chlorophenyl)formamido)ethyl formate 
• 10282-31-2 4-morpholinobenzonitrile 
• 1454654-38-6 [5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-yl]-(4-morpholin-4-yl-phenyl)-amine 
• 1454654-29-5 (4-morpholin-4-yl-phenyl)-(5-quinolin-3-yl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-amine 
• 1454654-40-0 (5-biphenyl-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-(4-morpholin-4-yl-phenyl)-amine 
• 1454654-35-3 2-methyl-2-{4-[2-(4-morpholin-4-yl-phenylamino)-[1,2,4]triazolo[1,5-a]pyrazin-5-yl]-phenyl}-propionitrile 
• 1454654-31-9 (4-morpholin-4-yl-phenyl)-(5-quinolin-6-yl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-amine 
• 1454654-28-4 (4-morpholin-4-yl-phenyl)-{5-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazol-4-yl]-[1,2,4]triazolo[1,5-a]pyrazin-2-yl}-amine 

Relevant articles and documents

Effect of Precatalyst Oxidation State in C-N Cross-Couplings with 2-Phosphinoimidazole-Derived Bimetallic Pd(I) and Pd(II) Complexes

We report the catalytic activity of two phosphinoimidazole-derived bimetallic palladium complexes in Pd-catalyzed amination reactions. Our studies demonstrate that the starting oxidation state (Pd(I) or Pd(II)) of the dimeric complex has a significant effect on the efficiency of the catalytic reaction. The corresponding Pd(I) complex shows higher reactivity in Buchwald-Hartwig aminations, while the Pd(II) complex is much more reactive in carbonylative amination reactions. These new dimeric palladium complexes provide good to excellent reactivity and yields in the amination reactions tested.

N-heterocyclic carbene-Pd(II)-2-methyl-4,5-dihydrooxazole complex-catalyzed highly chemoselective mono-amination of dichlorobenzenes

The palladium-catalyzed chemoselective mono-amination of dichlorobenzenes was reported in this paper. Under the suitable conditions, all reactions involving the three isomers of dichlorobenzenes with various secondary and primary amines in the presence of

Catalyst-free photodecarbonylation ofortho-amino benzaldehyde

It is almost a consensus that decarbonylation of the aldehyde group (-CHO) needs to not only be mediated by transition metal catalysts, but also requires severe reaction conditions (high temperature and long reaction time). In this work, inspired by the “conformational-selectivity-based” design strategy, we broke this consensus and discovered a catalyst-free photodecarbonylation of the aldehyde group. It revealed that decarbonylation can be easily achieved with visible light irradiation by introducing a tertiary amine into theortho-position of the aldehyde group. A diverse array of tertiary amines is tolerated by our photodecarbonylation under mild conditions. Furthermore, the (QM) computations of the mechanism and the experiments on well-designed special substrates revealed that our photodecarbonylation depends on the conformational specificity of the aldehyde group and tertiary amine, and occurs through an unusual [1,4]-H shift and a subsequent [1,3]-H shift.