1033804-86-2

Usage

Uses

Used in Pharmaceutical Industry:
L-Phenylalanine, 4-(2-aMino-6-chloro-4-pyriMidinyl)-N-[(1,1-diMethylethoxy)carbonyl]is used as a precursor in the synthesis of various medications for its ability to contribute to the development of new pharmaceutical compounds.
Used in Medical Research:
L-Phenylalanine, 4-(2-aMino-6-chloro-4-pyriMidinyl)-N-[(1,1-diMethylethoxy)carbonyl]is utilized as a research tool in the exploration of potential therapeutic applications, particularly in the treatment of certain diseases, due to its unique structure and properties.
Used in Drug Development:
L-Phenylalanine, 4-(2-aMino-6-chloro-4-pyriMidinyl)-N-[(1,1-diMethylethoxy)carbonyl]is employed as a building block in drug development, where its integration into new molecular structures could lead to the creation of innovative treatments for a range of medical conditions.

Upstream product

• 56-05-3 2-Amino-4,6-dichloropyrimidine 
• 119771-23-2 N-(tert-butoxycarbonyl)-4-(dihydroxyboryl)-1-phenylalanine 
• 216439-76-8 (S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate 
• 1143525-81-8 (S)-2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid, lithium salt 
• 1116460-10-6 (S)-3-(4-(2-amino-6-chloropyrimidin-4-yl)phenyl)-2-(tert-butoxycarbonylamino)propanoic acid, tert-butylamine salt 

Downstream Products

• 1116460-10-6 (S)-3-(4-(2-amino-6-chloropyrimidin-4-yl)phenyl)-2-(tert-butoxycarbonylamino)propanoic acid, tert-butylamine salt 
• 945976-76-1 (S)-2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-methoxy-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidin-4-yl)phenyl)-propanoic acid 
• 1116459-96-1 (S)-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-methoxy-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidin-4-yl)phenyl)-2-((tertbutoxycarbonyl)amino)propanoic acid 
• 1033805-99-0 (S)-3-[4-(2-amino-6-{(S)-2,2,2-trifluoro-1-(4-isoxazol-4-yl-phenyl)ethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid 
• 1033805-98-9 (S)-2-amino-3-(4-{2-amino-6-[(S)-2,2,2-trifluoro-1-[4-(1,2-oxazol-4-yl)phenyl]ethoxy]pyrimidin-4-yl}phenyl)propanoic acid 
• 1033805-97-8 (S)-3-[4-(2-amino-6-{(S)-2,2,2-trifluoro-1-[4-(4-trifluoromethylpyridin-3-yl)phenyl]ethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid 
• 1033805-96-7 (S)-2-amino-3-[4-(2-amino-6-{(S)-2,2,2-trifluoro-1-[4-(4-trifluoromethyl-pyridin-3-yl)-phenyl]-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid 
• 1033805-95-6 (S)-3-[4-(2-amino-6-{(S)-2,2,2-trifluoro-1-[4-(5-methoxypyridin-3-yl)phenyl]ethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid 
• 1033805-94-5 (S)-2-amino-3-[4-(2-amino-6-{(S)-2,2,2-trifluoro-1-[4-(5-methoxy-pyridin-3-yl)-phenyl]-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid 
• 1033805-93-4 (S)-3-[4-(2-amino-6-{(S)-2,2,2-trifluoro-1-[4-(2-fluoropyridine-4-yl)phenyl]ethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid 
• 1033805-91-2 (S)-2-amino-3-[4-(2-amino-6-{(S)-2,2,2-trifluoro-1-[4-(2-fluoro-pyridin-4-yl)-phenyl]-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid 
• 1033805-28-5 (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)-phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid 
• 1033805-27-4 (S)-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)-2-(tert-butoxycarbonylamino)propanoic acid 
• 1033805-84-3 (S)-2-amino-3-[4-(2-amino-6-{2,2,2-trifluoro-1-[4-(6-methoxy-pyridin-2-yl)-phenyl]-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid 

Relevant academic research and scientific papers

Process Development of Tryptophan Hydroxylase Inhibitor LX1031, a Drug Candidate for the Treatment of Irritable Bowel Syndrome

Two process routes for LX1031, a tryptophan hydroxylase inhibitor for the treatment of irritable bowel syndrome, were developed. They shared the same left-hand and right-hand starting materials as well as the penultimate intermediate. The chiral center in

PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES

Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed:

SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL- 4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL) PROPANOIC ACID AND METHODS OF THEIR USE

Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-methoxybiphenyl-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid and salts thereof are disclosed

Process for the preparation of substituted phenylalanines

Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed:

METHODS OF PREPARING 4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS

Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.

SOLID FORMS OF (S)-ETHYL 2-AMINO-3-(4-(2-AMINO-6-((R)-1-(4-CHLORO-2-(3-METHYL-1H-PYRAZOL-1-YL)PHENYL)-2,2,2-TRIFLUOROETHOXY)-PYRIMIDIN-4-YL)PHENYL)PROPANOATE AND METHODS OF THEIR USE

Solid forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate and salts thereof are disclosed.