L-Phenylalanine, 4-(2-aMino-6-chloro-4-pyriMidinyl)-N-[(1,1-diMethylethoxy)carbonyl]-

Base Information

Chemical Name:L-Phenylalanine, 4-(2-aMino-6-chloro-4-pyriMidinyl)-N-[(1,1-diMethylethoxy)carbonyl]-
CAS No.:1033804-86-2
Molecular Formula:C18H21ClN4O4
Molecular Weight:392.842
Hs Code.:2933599090
Mol file:1033804-86-2.mol

Synonyms:L-Phenylalanine, 4-(2-aMino-6-chloro-4-pyriMidinyl)-N-[(1,1-diMethylethoxy)carbonyl]-;(S)-3-(4-(2-amino-6-chloropyrimidin-4-yl)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid;(2S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid;LX1606 intermediate;(S)-3-[4-(2-Amino-6-chloropyrimidin-4-yl)phenyl]-2-[(tert-butoxycarbonyl)amino]propionic acid;4-(2-Amino-6-chloro-4-pyrimidinyl)-N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanine;(2S)-3-[4-(2-Amino-6-chloropyrimidin-4-yl)phenyl]-2-[(tert-butoxycarbonyl)amino]propionic acid;1033804-86-2

Suppliers and Price of L-Phenylalanine, 4-(2-aMino-6-chloro-4-pyriMidinyl)-N-[(1,1-diMethylethoxy)carbonyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(S)-3-(4-(2-AMINO-6-CHLOROPYRIMIDIN-4-YL)PHENYL)-2-((TERT-BUTOXYCARBONYL)AMINO)PROPANOIC ACID 95.00%
5MG
$ 495.83

American Custom Chemicals Corporation
(S)-3-(4-(2-AMINO-6-CHLOROPYRIMIDIN-4-YL)PHENYL)-2-((TERT-BUTOXYCARBONYL)AMINO)PROPANOIC ACID 95.00%
1G
$ 1080.45

Chemenu
(S)-3-(4-(2-amino-6-chloropyrimidin-4-yl)phenyl)-2-((tert-butoxycarbonyl)amino)propanoicacid 95%
1g
$ 482.00

Crysdot
(S)-3-(4-(2-Amino-6-chloropyrimidin-4-yl)phenyl)-2-((tert-butoxycarbonyl)amino)propanoicacid 95+%
1g
$ 515.00

Total 58 raw suppliers

Chemical Property of L-Phenylalanine, 4-(2-aMino-6-chloro-4-pyriMidinyl)-N-[(1,1-diMethylethoxy)carbonyl]-

Chemical Property:

PSA：127.43000
LogP:3.87170
Storage Temp.:2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(S)-3-(4-(2-AMINO-6-CHLOROPYRIMIDIN-4-YL)PHENYL)-2-((TERT-BUTOXYCARBONYL)AMINO)PROPANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Phenylalanine, 4-(2-aMino-6-chloro-4-pyriMidinyl)-N-[(1,1-diMethylethoxy)carbonyl]-

There total 8 articles about L-Phenylalanine, 4-(2-aMino-6-chloro-4-pyriMidinyl)-N-[(1,1-diMethylethoxy)carbonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 56-05-3
2-Amino-4,6-dichloropyrimidine

: 1143525-81-8
(S)-2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid, lithium salt

: 1033804-86-2
(S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid

Guidance literature:: With potassium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; at 70 ℃; for 7h; Product distribution / selectivity;

Reference yield: 89.5%

: 1116460-10-6
(S)-3-(4-(2-amino-6-chloropyrimidin-4-yl)phenyl)-2-(tert-butoxycarbonylamino)propanoic acid, tert-butylamine salt

: 1033804-86-2
(S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; toluene; at 60 ℃; pH=4.0; Purification / work up;

Reference yield: 84.0%

: 216439-76-8
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate

: 56-05-3
2-Amino-4,6-dichloropyrimidine

: 1033804-86-2
(S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid

Guidance literature:: (S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate; 2-Amino-4,6-dichloropyrimidine; bis-triphenylphosphine-palladium(II) chloride; In ethanol; for 0.333333h;

With water; potassium hydrogencarbonate; In ethanol; at 45 - 75 ℃;

With citric acid; In water; at 60 ℃; for 2h; pH=4.0; Product distribution / selectivity;