1034020-28-4Relevant academic research and scientific papers
Development of a practical and scalable synthesis of a potent CRTH2 antagonist
Yoshida, Shinya,Yoshino, Toshitaka,Miyafuji, Akio,Yasuda, Hironobu,Kimura, Takenori,Takahashi, Takumi,Mukuta, Takashi
, p. 1544 - 1551 (2013/02/23)
This contribution describes the process research and development of a practical and scalable synthetic method towards compound 1, which has a potent CRTH2 antagonistic activity. The medicinal chemistry synthetic route and second generation synthetic route
POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS
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Page/Page column 77, (2008/12/06)
The present invention relates to a novel compound or a salt thereof, which is useful as a CRTH2 antagonist, especially as a medicament for disorder that participates eosinophil, for example, allergic disorder such as asthma, allergic rhinitis, allergic dermatitis, conjunctival inflammation, hives, eosinophilic bronchitis, food allergy, inflammation of the nasal sinuses, multiple sclerosis, angiitis, or chronic obstructive pulmonary disease (COPD) and the like.
