1034025-91-6

Basic information

• Product Name: 1,3-diethyl (2,5-difluoro-4-nitrophenyl)propanedioate
• Synonyms: 1,3-diethyl (2,5-difluoro-4-nitrophenyl)propanedioate
• CAS NO: 1034025-91-6
• Molecular Weight: 317.246
• Mol File: 1034025-91-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,3-diethyl (2,5-difluoro-4-nitrophenyl)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-diethyl (2,5-difluoro-4-nitrophenyl)propanedioate(1034025-91-6)
• EPA Substance Registry System: 1,3-diethyl (2,5-difluoro-4-nitrophenyl)propanedioate(1034025-91-6)

Safety Data

• Hazardous Substances Data: 1034025-91-6(Hazardous Substances Data)

Upstream product

• 14064-10-9 diethyl 2-chloromalonate 
• 2105-61-5 1,2,4-trifluoro-5-nitrobenzene 
• 105-53-3 diethyl malonate 

Downstream Products

• 1034025-94-9 1,3-diethyl 2-(4-amino-2,5-difluorophenyl)propanedioate 
• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 1374573-64-4 [2,5-difluoro-4-(1H-tetrazol-1-yl)phenyl]acetic acid 
• 1260893-58-0 2-(4-amino-2,5-difluorophenyl)acetic acid 
• 770719-22-7 (2,5-difluoro-4-nitrophenyl)acetic acid 

Relevant articles and documents

A 2, 4, 5-trifluorophenylacetic acid method for the preparation of

The invention discloses a preparation method 2,4,5-trifluorophenylacetic acid. The method is characterized by consisting of four reaction steps of: A, reaction of 2,4,5-trifluoronitrobenzene (I) and diethyl malonate which are condensed to prepare 2,5-difloro-4-nitrobenzophenone diethyl malonate; B, hydrolysis, acidification and decarboxylic reaction of dibasic ester; C, reduction reaction of nitryl; and D, diazotization fluoridation of amino. The four reaction steps can be sequentially carried out according to A, B, C and D, or A, C, B and D, or A, C, D and B. According to the preparation method provided by the invention, condensation of 2,4,5-trifluoronitrobenzene (I) and diethyl malonate is easy to realize by means of high substituting activity of nitryl p-fluorine, and the raw material 2,4,5-trifluoronitrobenzene (I) is low in cost and easy to obtain and can be easily prepared by nitration and fluorination of 2,4-dichlor fluorbenzene. Compared with the prior art, the preparation method provided by the invention has the characteristics of low-cost and easily obtained raw materials, mild reaction condition, high total yield, low production cost and the like, and is comparatively suitable for industrialized production.

INHIBITORS OF RENAL OUTER MEDULLARY POTASSIUM CHANNEL

Novel spirocyclic compounds of formula I: and pharmaceutically acceptable salts thereof are disclosed as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Pharmaceutical compositions and methods of treatment are also included.

BENZAMIDE DERIVATIVES AS EP4 RECEPTOR AGONISTS

A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R1, R2, R3, R4, R5, m, n and X are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.