103407-24-5

Basic information

• Product Name: Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide
• Synonyms: Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide
• CAS NO: 103407-24-5
• Molecular Weight: 393.441
• Mol File: 103407-24-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide(103407-24-5)
• EPA Substance Registry System: Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide(103407-24-5)

Safety Data

• Hazardous Substances Data: 103407-24-5(Hazardous Substances Data)

Upstream product

• 41507-35-1 3-thiophene carboxylic acid chloride 
• 103343-37-9 1,3-dihydro-5-(2'-fluorophenyl)-3(R,S)-(aminomethyl)-2H-1,4-benzodiazepin-2-one 
• 103343-35-7 N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide 

Relevant articles and documents

Cholecystokinin-A Receptor Ligands Based on the κ-Opioid Agonist Tifluadom

Tifluadom, a k-opioid agonist and cholecystokinin-A (CCK-A) receptor antagonist, was utilized as a model to prepare a series of 2-(aminomethyl)- and 3-(aminomethyl)-1,4-benzodiazepines.These compounds were tested in vitro as inhibitors of the binding of CCK to rat pancreas and guinea pig brain receptors.All compounds with IC50's less than 100 μM proved to have greater affinity for the CCK-A receptor, with the most potent analogue, 6e, having an IC50 of 0.16 μM.The benzodiazepines described in this study are simultaneously CCK-A and opioid receptor ligands.The ramification of this dichotomy on current concepts of peptide horm one action are discussed.These results further demonstrate the versatility of the benzodiazepine core structure for designing nonpeptide ligands for peptide receptors and the ability to fine-tune the receptor interactions of these benzodiazepines by appropiate structure modifications.