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5-cyclopropyl-2-fluoropyridine is a pyridine derivative with the molecular formula C7H6FN. It features a cyclopropyl group and a fluorine atom attached to the second position of the pyridine ring. This chemical compound is known for its unique chemical and physical properties, which arise from the presence of the cyclopropyl and fluorine substituents. Its structural features make it a valuable intermediate in organic chemistry and a promising candidate for drug design and development, particularly in the fields of medicinal chemistry and drug discovery research.

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  • 1034467-80-5 Structure
  • Basic information

    1. Product Name: 5-cyclopropyl-2-fluoropyridine
    2. Synonyms: 5-cyclopropyl-2-fluoropyridine;5-Cyclopropyl-2-flluoropyridine
    3. CAS NO:1034467-80-5
    4. Molecular Formula: C8H8FN
    5. Molecular Weight: 137.1542232
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1034467-80-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Inert atmosphere,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-cyclopropyl-2-fluoropyridine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-cyclopropyl-2-fluoropyridine(1034467-80-5)
    11. EPA Substance Registry System: 5-cyclopropyl-2-fluoropyridine(1034467-80-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1034467-80-5(Hazardous Substances Data)

1034467-80-5 Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
5-cyclopropyl-2-fluoropyridine is used as a building block in the synthesis of pharmaceuticals and agrochemicals. Its unique properties and structural features make it a valuable intermediate for the development of new drugs and agrochemicals with improved efficacy and selectivity.
Used in Medicinal Chemistry Research:
5-cyclopropyl-2-fluoropyridine is used as a key intermediate in medicinal chemistry research for the design and synthesis of novel compounds with potential therapeutic applications. Its unique structural features allow for the exploration of new chemical space and the development of innovative drug candidates.
Used in Drug Discovery Research:
In drug discovery research, 5-cyclopropyl-2-fluoropyridine is employed as a starting material for the synthesis of diverse chemical libraries. Its unique properties enable the generation of a wide range of structurally diverse compounds, facilitating the identification of new lead compounds with potential therapeutic activity.
Used in Organic Chemistry:
5-cyclopropyl-2-fluoropyridine is utilized as a versatile intermediate in organic chemistry for the synthesis of various organic compounds. Its unique structural features and reactivity make it a valuable building block for the preparation of complex organic molecules and the development of new synthetic methodologies.

Check Digit Verification of cas no

The CAS Registry Mumber 1034467-80-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,4,4,6 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1034467-80:
(9*1)+(8*0)+(7*3)+(6*4)+(5*4)+(4*6)+(3*7)+(2*8)+(1*0)=135
135 % 10 = 5
So 1034467-80-5 is a valid CAS Registry Number.

1034467-80-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Cyclopropyl-2-fluoropyridine

1.2 Other means of identification

Product number -
Other names 5-cyclopropyl-2-fluoro-pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1034467-80-5 SDS

1034467-80-5Downstream Products

1034467-80-5Relevant articles and documents

PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND THEIR USE

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Paragraph 0432-0433, (2021/09/26)

The present invention provides, in part, novel small molecule inhibitors of PHD, having a structure according to Formula (A), and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for treatmen

Anti-tumor activity with acetylene derivatives

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Paragraph 0229-0232, (2016/10/08)

The present invention relates to an aromatic ring disubstituted acetylene derivative of formula I, a pharmaceutical composition comprising the compound, and a use of the compound and of the pharmaceutical composition in the treatment and/or prevention of tumors, where A, B, T, M, Ra, Rb, Rt, m, n, and p are as defined in the present document.

PYRAZOLE DERIVATIVES AS DIHYDROOROTATE DEHYDROGENASE (DHODH) INHIBITORS

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Page/Page column 97, (2015/11/03)

The present invention relates to compounds of formula (I) for their use in the treatment and/or prevention of auto-immune or auto-immune related diseases, cancer, viral infections, and central nervous system diseases and disorders, by inhibiting human deh

Original 2-(3-Alkoxy-1 H -pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

Lucas-Hourani, Marianne,Munier-Lehmann, Hélène,El Mazouni, Farah,Malmquist, Nicholas A.,Harpon, Jane,Coutant, Eloi P.,Guillou, Sandrine,Helynck, Olivier,Noel, Anne,Scherf, Artur,Phillips, Margaret A.,Tangy, Frédéric,Vidalain, Pierre-Olivier,Janin, Yves L.

, p. 5579 - 5598 (2015/08/03)

Following our discovery of human dihydroorotate dehydrogenase (DHODH) inhibition by 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as well as 2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)-5-methylpyridine, we describe here the syntheses and evaluation of an array of azine-bearing analogues. As in our previous report, the structure-activity study of this series of human DHODH inhibitors was based on a phenotypic assay measuring measles virus replication. Among other inhibitors, this round of syntheses and biological evaluation iteration led to the highly active 5-cyclopropyl-2-(4-(2,6-difluorophenoxy)-3-isopropoxy-5-methyl-1H-pyrazol-1-yl)-3-fluoropyridine. Inhibition of DHODH by this compound was confirmed in an array of in vitro assays, including enzymatic tests and cell-based assays for viral replication and cellular growth. This molecule was found to be more active than the known inhibitors of DHODH, brequinar and teriflunomide, thus opening perspectives for its use as a tool or for the design of an original series of immunosuppressive agent. Moreover, because other series of inhibitors of human DHODH have been found to also affect Plasmodium falciparum DHODH, all the compounds were assayed for their effect on P. falciparum growth. However, the modest in vitro inhibition solely observed for two compounds did not correlate with their inhibition of P. falciparum DHODH.

IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER

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Page/Page column 19, (2008/12/06)

The present invention provides novel imidazolidinonyl aminopyrimidine compounds believed to have clinical use for treatment of cancer through inhibiting Plk1. Formula I wherein: R1 is aminomethyl, (C1-C3 alkyl)aminomethyl, di(C1-C2 alkyl)aminomethyl, N- ethyl-N-methyl-aminomethyl, 1-aminoethyl, 1-((C1-C2 alkyl)amino)-ethyl, 3,3,3- trifluoropropylaminomethyl, ethynyl, 2-hydroxy-ethoxy, 2-hydroxyethylaminomethyl, 2- cyanoethylaminomethyl, mopholin-4-ylmethyl, methoxymethoxymethyl, cyclopropyl, 1- azetidinylmethyl, 1-pyrrolidinylmethyl, or 1,3-dioxolan-2-yl; R2 is hydrogen or halo; R3 is hydrogen or halo; provided that at least one of R2 and R3 is hydrogen; R4 is hydrogen, methyl, or halo; and is a single bond that is either present or absent, or a pharmaceutically acceptable salt thereof.

TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS

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Page/Page column 13, (2009/01/20)

The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.

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