103450-87-9

Basic information

• Product Name: ClarithroMycin 9-OxiMe
• Synonyms: ClarithroMycin 9-OxiMe;6-O-MethylerythroMycin 9-OxiMe;6-O-MethylerythroMycin A 9-OxiMe;Clarithromycin (9E)-Oxime;(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,E)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltet
• CAS NO: 103450-87-9
• Molecular Formula: C₃₈H₇₀N₂O₁₃
• Molecular Weight: 762.968
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents;Impurities;Chiral Reagents, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 103450-87-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 169-171 °C
• Boiling Point: 827.7±65.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 11.94±0.70(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: ClarithroMycin 9-OxiMe(CAS DataBase Reference)
• NIST Chemistry Reference: ClarithroMycin 9-OxiMe(103450-87-9)
• EPA Substance Registry System: ClarithroMycin 9-OxiMe(103450-87-9)

Safety Data

• Hazardous Substances Data: 103450-87-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Clarithromycin 9-Oxime is an impurity of Clarithromycin (C559750), a macrolide antibiotic.

Upstream product

• 81103-11-9 clarithromycin 
• 81103-09-5 2'-O,3'-N-bis(benzyloxycarbonyl)-N-demethylerythromycin A 
• 50-00-0 formaldehyd 
• 101666-67-5 6-O-methyl-N-demethylerythromycin A 9-oxime 
• 101666-16-4 C₅₂H₇₈N₂O₁₇ 
• 101666-16-4 C₅₂H₇₈N₂O₁₇ 
• 101666-32-4 C₅₉H₈₄N₂O₁₇ 
• 101670-80-8 C₆₀H₈₆N₂O₁₇ 

Relevant articles and documents

3-keto-9-O-substituted oxime derivatives of 6-O-methyl erythromycin A synthesis and in vitro activity

A series of 3-keto-9-O-substituted oxime derivatives of 6-O-methyl erythromycin A were prepared with a novel synthetic route, which include 6 reaction steps-oximation, protection, hydrolysis, oxidation, deprotection and addition. The antibacterial activit

PROCESS FOR THE PREPARATION OF 6-O-METHYLERYTHROMYCIN A 9-OXIME

The present invention relates to process for the preparation of 6-O-methylerythromycin A 9-oxime by treating 6-O-methylerythromycin A with hydroxyl amine hydrochloride in the presence of a base and a solvent.