3-keto-9-O-substituted oxime derivatives of 6-O-methyl erythromycin A synthesis and in vitro activity

Article abstract of DOI:10.7164/antibiotics.54.506

A series of 3-keto-9-O-substituted oxime derivatives of 6-O-methyl erythromycin A were prepared with a novel synthetic route, which include 6 reaction steps-oximation, protection, hydrolysis, oxidation, deprotection and addition. The antibacterial activit