103474-02-8

Basic information

• Product Name: methyl 2-(2-phenoxyphenyl)acetate
• Synonyms: methyl 2-(2-phenoxyphenyl)acetate
• CAS NO: 103474-02-8
• Molecular Weight: 242.274
• Mol File: 103474-02-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl 2-(2-phenoxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(2-phenoxyphenyl)acetate(103474-02-8)
• EPA Substance Registry System: methyl 2-(2-phenoxyphenyl)acetate(103474-02-8)

Safety Data

• Hazardous Substances Data: 103474-02-8(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 22446-37-3 methyl (2-hydroxyphenyl)acetate 
• 2243-42-7 2-phenoxybenzoic acid 
• 5888-53-9 2-phenoxybenzyl chloride 
• 13807-84-6 (2-phenoxyphenyl)methanol 
• 25563-02-4 2-(2-phenoxyphenyl)acetic acid 
• 462-06-6 fluorobenzene 
• 98-80-6 phenylboronic acid 

Downstream Products

• 159731-09-6 2-(2-phenoxyphenyl)acetic acid hydrazide 
• 25563-02-4 2-(2-phenoxyphenyl)acetic acid 
• 1030829-49-2 2-(2-phenoxyphenyl)ethan-1-ol 
• 1391575-74-8 2-(2-phenoxyphenyl)acetaldehyde 

Relevant articles and documents

MALIC ENZYME INHIBITORS

The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents

Mycobacterium tuberculosis, the causative agent of tuberculosis, relies on thymidylate kinase (MtbTMPK) for the synthesis of thymidine triphosphates and thus also DNA synthesis. Therefore, this enzyme constitutes a potential Achilles heel of the pathogen. Based on a previously reported MtbTMPK 6-aryl-substituted pyridone inhibitor and guided by two co-crystal structures of MtbTMPK with pyridone- and thymine-based inhibitors, we report the synthesis of a series of aryl-shifted cyanopyridone analogues. These compounds generally lacked significant MtbTMPK inhibitory potency, but some analogues did exhibit promising antitubercular activity. Analogue 11i demonstrated a 10-fold increased antitubercular activity (MIC H37Rv, 1.2 μM) compared to literature compound 5. Many analogues with whole-cell antimycobacterial activity were devoid of significant cytotoxicity.

Fungicides

Compounds of formula: ψψ and stereoisomers thereof, wherein X, Y and Z, which may be the same or different, are hydrogen or halogen atoms, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted alkynyl, haloalkyl, alkoxy, haloalkoxy, optionally substituted aryloxy, optionally substituted arylalkoxy, optionally substituted acyloxy, optionally substituted amino, optionally substituted arylazo, acylamino, nitro, nitrile, -CO2R3, -CONR4R5, -COR6, -CR7=NR8, or -N=CR9R10 groups; or the groups X and Y, when they are in adjacent positions on the phenyl ring, may join to form a fused ring, either aromatic or aliphatic, optionally containing one or more heteroatoms; and R1, Ry, R3, R4, R5, R6, R7, R8, R9 and R10, which may be the same or different, are hydrogen atoms or alkyl, cycloalkyl, alkenyl, alkynyl, optionally substituted aryl, optionally substituted aralkyl, or cycloalkylalkyl groups; and metal complexes thereof.ψ