1034767-29-7Relevant academic research and scientific papers
Iron-catalyzed oxidative sp3 carbon-hydrogen bond functionalization of 3,4-dihydro-1,4-benzoxazin-2-ones
Huo, Congde,Dong, Jie,Su, Yingpeng,Tang, Jing,Chen, Fengjuan
supporting information, p. 13341 - 13344 (2016/11/18)
A novel and efficient iron-catalyzed sp3 carbon-hydrogen bond functionalization of benzoxazinone derivatives has been developed. For the first time, benzoxazin-2-ones were used as substrates in an oxidative dehydrogenative coupling reaction. The experiments were performed under mild reaction conditions to construct alkyl-aryl C(sp3)-C(sp2) bonds. The application of this method to the gram-scale synthesis of natural product cephalandole A has been accomplished in a 3-step sequence. A plausible one electron oxidation involved mechanism is proposed.
A convenient synthesis of 3,4-dihydro-1,4-benzoxazin-2-ones
Zidar, Nace,Kikelj, Danijel
, p. 5756 - 5761 (2008/09/21)
3,4-Dihydro-1,4-benzoxazin-2-one was prepared for the first time by catalytic hydrogenation of 4-benzyl-3,4-dihydro-1,4-benzoxazin-2-one. A simple and efficient synthesis of 4-benzyl- and 4-alkyl-3,4-dihydro-1,4-benzoxazin-2-one derivatives from ethyl 2-(2-hydroxyphenylamino)acetate and aldehydes is described. Some considerations regarding the reactivity of 3,4-dihydro-1,4-benzoxazin-2-ones are given.
