1034769-89-5

Upstream product

• 173341-02-1 N-(morpholin-2-ylmethyl)carbamic acid tert-butyl ester 
• 370866-02-7 5-bromo-4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine 

Downstream Products

• 1034769-90-8 tert-butyl (4-(1-(4-methoxybenzyl)-5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl)methylcarbamate 
• 1174913-79-1 tert-butyl (4-(1-(4-methoxybenzyl)-5-(thiophen-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl)methylcarbamate 

Relevant academic research and scientific papers

Identification of inhibitors of checkpoint kinase 1 through template screening

Checkpoint kinase 1 (CHK1) is an oncology target of significant current interest. Inhibition of CHK1 abrogates DNA damage-induced cell cycle checkpoints and sensitizes p53 deficient cancer cells to genotoxic therapies. Using template screening, a fragment

MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS

The present invention pertains generally to the field of therapeutic compounds, and mor specifically to certain morpholino-substituted bicydoheteroaryl compounds (referred to herein as MBHA compounds), of the following formula: and especially certain morp