1035040-47-1

Basic information

• Product Name: (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide
• Synonyms: (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide
• CAS NO: 1035040-47-1
• Molecular Weight: 492.928
• Mol File: 1035040-47-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide(1035040-47-1)
• EPA Substance Registry System: (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide(1035040-47-1)

Safety Data

• Hazardous Substances Data: 1035040-47-1(Hazardous Substances Data)

Upstream product

• 955359-79-2 4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone 
• 67680-56-2 2,2,2-trifluoro-N-(2-iodoethyl)acetamide 

Downstream Products

• 1035040-49-3 (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoro-N-methylacetamide 
• 1035040-52-8 (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxy-N-methylbutanamide trifluoroacetate salt 

Relevant articles and documents

Design of Phthalazinone Amide Histamine H1 Receptor Antagonists for Use in Rhinitis

The synthesis of potent amide-containing phthalazinone H1 histamine receptor antagonists is described. Three analogues 3e, 3g, and 9g were equipotent with azelastine and were longer-acting in vitro. Amide 3g had low oral bioavailability, low brain-penetration, high metabolic clearance, and long duration of action in vivo, and it was suitable for once-daily dosing intranasally, with a predicted dose for humans of approximately 0.5 mg per day.