(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide
• CAS No.: 1035040-47-1
• Molecular Formula: C₂₄H₂₄ClF₃N₄O₂
• Molecular Weight: 492.928

Synonyms:(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide

Chemical Property of (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide

Chemical Property:

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Technology Process of (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide

There total 1 articles about (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone (955359-79-2) + 2,2,2-trifluoro-N-(2-iodoethyl)acetamide (67680-56-2) → (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide (1035040-47-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In butanone;

Reference yield:

MeOH-water + (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide (1035040-47-1) + methyl iodide (74-88-4) → (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoro-N-methylacetamide (1035040-49-3)

Guidance literature:

With potassium carbonate; In methanol; N,N-dimethyl-formamide;

Reference yield:

(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoroacetamide (1035040-47-1) + methyl iodide (74-88-4) → (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoro-N-methylacetamide (1035040-49-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1021/acsmedchemlett.7b00112

upstream raw materials:

4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

2,2,2-trifluoro-N-(2-iodoethyl)acetamide

Downstream raw materials:

(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-2,2,2-trifluoro-N-methylacetamide

(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)-4-methoxy-N-methylbutanamide trifluoroacetate salt

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