1035155-54-4

Usage

Benzene derivative

It is derived from benzene, a basic structure consisting of a six-carbon ring with alternating single and double bonds.

Bromine atom

A halogen atom (Br) is attached to one of the carbon atoms in the benzene ring.

Fluorine atoms

Two fluorine atoms (F) are attached to the benzene ring, providing unique reactivity and properties.

Benzyloxy group

A benzene ring with an attached oxygen atom (O) and a benzyl group (C6H5-CH2-), which is a phenylmethyl group.

Versatile reactivity

The compound can participate in various chemical reactions due to the presence of multiple functional groups.

Pharmaceutical research

It is used in the development of new drugs and pharmaceutical compounds.

Organic synthesis

The compound is utilized in the creation of complex organic molecules.

Toxicity

It can be toxic and harmful if not handled properly.

Controlled environments

It should be used and stored in controlled environments to minimize the risk of exposure and harm.

Proper management

Careful handling and safety precautions are necessary when working with 1-Bromo-3-benzyloxy-4,5-difluorobenzene.

Upstream product

• 100-39-0 benzyl bromide 

Downstream Products

• 1035155-56-6 ethyl {3,4-difluoro-5-[(phenylmethyl)oxy]phenyl}acetate 

Relevant academic research and scientific papers

Tetrahydropyridino aromatic heterocyclic inhibitor as well as preparation method and application thereof

The invention discloses a hepatitis B virus surface antigen (HBsAg) secretion and HBV DNA generation inhibitor, provides a tetrahydropyridino aromatic heterocyclic compound with a structure shown in aformula (I), a stereoisomer, a tautomer or pharmaceutically acceptable salt, hydrate, solvate and prodrug thereof, and also provides a pharmaceutical composition of the pharmaceutically acceptable salt of the compound. The tetrahydropyridino aromatic heterocyclic compound can be used for treating and preventing viruses and related diseases.

NOVEL TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The invention provides novel compounds having the general formula (I): wherein R1, R2, R3, Q, U,W, Z, X and Y are as described herein, compositions including the compounds and methods of using the compounds. These compounds are HbsAg inhibitors and are useful as medicaments for the treatment or prophylaxis of HBV infection.

TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES AS INHIBITORS OF HBSAG (HBV SURFACE ANTIGEN) AND HBV DNA PRODUCTION FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTIONS

The present invention provides tetrahydropyridopyrimidines and tetrahydropyridopyridines having the general formula (I) wherein R1, R2, U, W, X, Y and Z are as described herein, as inhibitors of HBsAg (HBV surface antigen) and HBV DNA production for the treatment and prophylaxis of hepatitis B virus infections.

CALCILYTIC COMPOUNDS

Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.