1035173-87-5Relevant academic research and scientific papers
Nickel-catalyzed C-N bond activation: Activated primary amines as alkylating reagents in reductive cross-coupling
Yue, Huifeng,Zhu, Chen,Shen, Li,Geng, Qiuyang,Hock, Katharina J.,Yuan, Tingting,Cavallo, Luigi,Rueping, Magnus
, p. 4430 - 4435 (2019)
Nickel-catalyzed reductive cross coupling of activated primary amines with aryl halides under mild reaction conditions has been achieved for the first time. Due to the avoidance of stoichiometric organometallic reagents and external bases, the scope regarding both coupling partners is broad. Thus, a wide range of substrates, natural products and drugs with diverse functional groups are tolerated. Moreover, experimental mechanistic investigations and density functional theory (DFT) calculations in combination with wavefunction analysis have been performed to understand the catalytic cycle in more detail.
SULFONAMIDE DERIVATIVES FOR THERAPEUTIC USE AS FATTY ACID SYNTHASE INHIBITORS
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Page/Page column 175-176, (2008/12/06)
A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for preparing such compounds, their use as Fatty Acid Synthase inhibitors, methods for their therapeutic use, particularly in the treatment of obesity and diabetes mellitus
