Chemical Science p. 4430 - 4435 (2019)
Update date:2022-08-04
Topics:
Yue, Huifeng
Zhu, Chen
Shen, Li
Geng, Qiuyang
Hock, Katharina J.
Yuan, Tingting
Cavallo, Luigi
Rueping, Magnus
Nickel-catalyzed reductive cross coupling of activated primary amines with aryl halides under mild reaction conditions has been achieved for the first time. Due to the avoidance of stoichiometric organometallic reagents and external bases, the scope regarding both coupling partners is broad. Thus, a wide range of substrates, natural products and drugs with diverse functional groups are tolerated. Moreover, experimental mechanistic investigations and density functional theory (DFT) calculations in combination with wavefunction analysis have been performed to understand the catalytic cycle in more detail.
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