1035232-28-0Relevant academic research and scientific papers
Discovery and optimization of pyrazoline compounds as B-Raf inhibitors
Duffey, Matthew O.,Adams, Ruth,Blackburn, Christopher,Chau, Ryan W.,Chen, Susan,Galvin, Katherine M.,Garcia, Khristofer,Gould, Alexandra E.,Greenspan, Paul D.,Harrison, Sean,Huang, Shih-Chung,Kim, Mi-Sook,Kulkarni, Bheemashankar,Langston, Steven,Liu, Jane X.,Ma, Li-Ting,Menon, Saurabh,Nagayoshi, Masayuki,Rowland, R. Scott,Vos, Tricia J.,Xu, Tianlin,Yang, Johnny J.,Yu, Shaoxia,Zhang, Qin
scheme or table, p. 4800 - 4804 (2010/10/04)
The discovery of novel pyrazoline derivatives as B-Raf (V600E) inhibitors is described in this report. Chemical modification of the pyrazoline scaffold led to the development of SAR and identified potent and selective inhibitors of B-Raf (V600E). Determin
