1035232-50-8Relevant academic research and scientific papers
Discovery and optimization of pyrazoline compounds as B-Raf inhibitors
Duffey, Matthew O.,Adams, Ruth,Blackburn, Christopher,Chau, Ryan W.,Chen, Susan,Galvin, Katherine M.,Garcia, Khristofer,Gould, Alexandra E.,Greenspan, Paul D.,Harrison, Sean,Huang, Shih-Chung,Kim, Mi-Sook,Kulkarni, Bheemashankar,Langston, Steven,Liu, Jane X.,Ma, Li-Ting,Menon, Saurabh,Nagayoshi, Masayuki,Rowland, R. Scott,Vos, Tricia J.,Xu, Tianlin,Yang, Johnny J.,Yu, Shaoxia,Zhang, Qin
scheme or table, p. 4800 - 4804 (2010/10/04)
The discovery of novel pyrazoline derivatives as B-Raf (V600E) inhibitors is described in this report. Chemical modification of the pyrazoline scaffold led to the development of SAR and identified potent and selective inhibitors of B-Raf (V600E). Determin
Certain pyrazoline derivatives with kinase inhibitory activity
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Page/Page column 107, (2008/12/06)
The present invention provides certain pyrazoline compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of various diseases.
