1035235-28-9

Basic information

• Product Name: N-BOC-isoindoline-4-boronic acid, pinacol ester
• Synonyms: N-BOC-isoindoline-4-boronic acid, pinacol ester;tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindoline-2-carboxylate;4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
• CAS NO: 1035235-28-9
• Molecular Formula: C₁₉H₂₈BNO₄
• Molecular Weight: 363.2562
• Mol File: 1035235-28-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 453.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.11±0.1 g/cm3(Predicted)
• PKA: -1.66±0.20(Predicted)
• CAS DataBase Reference: N-BOC-isoindoline-4-boronic acid, pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-isoindoline-4-boronic acid, pinacol ester(1035235-28-9)
• EPA Substance Registry System: N-BOC-isoindoline-4-boronic acid, pinacol ester(1035235-28-9)

Safety Data

• Hazardous Substances Data: 1035235-28-9(Hazardous Substances Data)

Usage

Uses

N-BOC-isoindoline-4-boronic acid, pinacol ester

Upstream product

• 923590-95-8 4-bromo-2,3-dihydro-1H-isoindole hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1035235-27-8 tert-butyl 4-bromo-2,3-dihydro-1H-isoindole-2-carboxylate 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 127168-73-4 4-methoxy-1H-isoindole 
• 871013-92-2 tert-butyl 4-hydroxy-1,3-dihydro-2H-isoindole-2-carboxylate 

Relevant articles and documents

INHIBITORS OF MLH1 AND/OR PMS2 FOR CANCER TREATMENT

The present invention relates to compounds of Formula (I) that target the MLH1 and/or PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: Formula (I) wherein R1, R2, R3, R4, R6

CARBAZOLE DERIVATIVES

Disclosed are compounds of Formula (I): (I) or a salt thereof, wherein Q, R1a, R1b, R2a, R2b, R3, R4, R5a, R5b, R6a, R6c, R7a, R7b, R7c, and R7d are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Certain pyrazoline derivatives with kinase inhibitory activity

The present invention provides certain pyrazoline compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of various diseases.